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Mouse Anti-GJB3 Recombinant Antibody (CBLG1-110) (CBMAB-G0493-LY)

This product is antibody recognizes GJB3. The antibody CBLG1-110 immunoassay techniques such as: ELISA, ICC, WB.
See all GJB3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBLG1-110
Antibody Isotype
IgG1
Application
ELISA, ICC, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.09% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
gap junction protein, beta 3, 31kDa
Introduction
This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
Entrez Gene ID
2707
UniProt ID
O75712
Alternative Names
Gap Junction Protein Beta 3; Gap Junction Protein; Beta 3; 31kDa; Connexin 31; CX31; Gap Junction Protein; Beta 3; 31kDa (Connexin 31); Gap Junction Protein; Beta 3; 31kD (Connexin 31); Erythrokeratodermia Variabilis;
Function
One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
Biological Process
Cell-cell signaling Source: GO_Central
Cellular response to retinoic acid Source: Ensembl
In utero embryonic development Source: Ensembl
Placenta development Source: Ensembl
Skin development Source: Ensembl
Spermatogenesis Source: Ensembl
Cellular Location
Cell membrane; Gap junction
Involvement in disease
Erythrokeratodermia variabilis et progressiva 1 (EKVP1):
A form of erythrokeratodermia variabilis et progressiva, a genodermatosis characterized by the coexistence of two independent skin lesions: transient erythema and hyperkeratosis that is usually localized but occasionally occurs in its generalized form. Clinical presentation varies significantly within a family and from one family to another. Palmoplantar keratoderma is present in around 50% of cases.
Deafness, autosomal dominant, 2B (DFNA2B):
A form of non-syndromic sensorineural deafness characterized by progressive high frequency hearing loss in adulthood, with milder expression in females.
Topology
Cytoplasmic: 1-20
Helical: 21-40
Extracellular: 41-75
Helical: 76-98
Cytoplasmic: 99-126
Helical: 127-149
Extracellular: 150-187
Helical: 188-210
Cytoplasmic: 211-270
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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