GNGT1

Heterotrimeric guanine nucleotide-binding proteins (G proteins) transduce extracellular signals received by transmembrane receptors to effector proteins. Transducin is a guanine nucleotide-binding protein found specifically in rod outer segments, where it mediates activation by rhodopsin of a cyclic GTP-specific (guanosine monophosphate) phosphodiesterase. Transducin is also referred to as GMPase. GNGT1 encodes the gamma subunit of transducin (Hurley et al., 1984 [PubMed 6438626]; Scherer et al., 1996 [PubMed 8661128]).[supplied by OMIM

Full Name

guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1

Function

Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Biological Process

Cardiac muscle cell apoptotic process Source: Ensembl
Cellular response to hypoxia Source: Ensembl
Eye photoreceptor cell development Source: Ensembl
G protein-coupled receptor signaling pathway Source: GO_Central
Phototransduction Source: Ensembl
Protein localization Source: Ensembl
Signal transduction Source: ProtInc

Cellular Location

Cell membrane