GORASP1

the Golgicomplex plays a key role in the sorting and modification of proteins exported from the endoplasmic reticulum. The protein encoded by this gene is a membrane protein involved in establishing the stacked structure of the Golgiapparatus. It is a caspase-3 substrate, and cleavage of this encoded protein contributes to Golgi fragmentation in apoptosis. This encoded protein can form a complex with the Golgimatrix protein GOLGA2, and this complex binds to the vesicle docking protein p115. Alternative splicing results in multiple transcript variants of this gene.
Full Name
golgi reassembly stacking protein 1
Function
Plays an important role in assembly and membrane stacking of the Golgi cisternae, and in the reassembly of Golgi stacks after breakdown during mitosis (PubMed:26363069).

Key structural protein required for the maintenance of the Golgi apparatus integrity: its caspase-mediated cleavage is required for fragmentation of the Golgi during apoptosis (By similarity).

Also mediates, via its interaction with GOLGA2/GM130, the docking of transport vesicles with the Golgi membranes (PubMed:16489344).

Mediates ER stress-induced unconventional (ER/Golgi-independent) trafficking of core-glycosylated CFTR to cell membrane (PubMed:21884936).
Biological Process
Establishment of protein localization to plasma membrane Source: UniProtKB
Golgi organization Source: UniProtKB
Negative regulation of dendrite morphogenesis Source: UniProtKB
Protein N-linked glycosylation Source: Ensembl
Protein transport Source: UniProtKB-KW
Cellular Location
Cis-Golgi network membrane; Endoplasmic reticulum-Golgi intermediate compartment membrane
PTM
Phosphorylated by CDC2/B1 and PLK kinases during mitosis. Phosphorylation cycle correlates with the cisternal stacking cycle. Phosphorylation of the homodimer prevents the association of dimers into higher-order oligomers, leading to cisternal unstacking.By similarity
Target for caspase-3 cleavage during apoptosis. The cleavage contributes to Golgi fragmentation and occurs very early in the execution phase of apoptosis.By similarity
Myristoylated.By similarity
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Anti-GORASP1 antibodies

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Rabbit Anti-GORASP1 Recombinant Antibody (Poly6210) (CBMAB-G4386-LY)

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Target: GORASP1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: Poly6210
Application*: IC, IF
Datasheet SDS

Mouse Anti-GORASP1 Recombinant Antibody (CBLG1-2887) (CBMAB-G4385-LY)

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Target: GORASP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2887
Application*: WB
Datasheet SDS

Mouse Anti-GORASP1 Recombinant Antibody (CBLG1-2886) (CBMAB-G4384-LY)

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Target: GORASP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2886
Application*: WB
Datasheet SDS

Mouse Anti-GORASP1 Recombinant Antibody (5G8) (CBMAB-G4381-LY)

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Target: GORASP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Monkey, Rat
Clone: 5G8
Application*: F
Datasheet SDS

Mouse Anti-GORASP1 Recombinant Antibody (5C5) (CBMAB-G4380-LY)

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Target: GORASP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat
Clone: 5C5
Application*: F
Datasheet SDS

Mouse Anti-GORASP1 Recombinant Antibody (4F8) (CBMAB-G4378-LY)

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Target: GORASP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4F8
Application*: IC/IF, WB
Datasheet SDS

Mouse Anti-GORASP1 Recombinant Antibody (CBFYH-0426) (CBMAB-H1297-FY)

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Target: GORASP1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Dog, Rat, Monkey
Clone: CBFYH-0426
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-GORASP1 Recombinant Antibody (CBFYH-0425) (CBMAB-H1296-FY)

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Target: GORASP1
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Dog, Rat
Clone: CBFYH-0425
Application*: WB, IH, IF, F
Datasheet SDS

Mouse Anti-GORASP1 Recombinant Antibody (CBFYH-0424) (CBMAB-H1295-FY)

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Target: GORASP1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0424
Application*: IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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