GPAA1

GPAA1 gene was frequently amplified (73%, 11/15) using quantitative microsatellite analysis.

Full Name

Glycosylphosphatidylinositol Anchor Attachment 1

Function

Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.

Biological Process

Attachment of GPI anchor to protein Source: GO_Central
Protein-containing complex assembly Source: UniProtKB
Protein retention in ER lumen Source: UniProtKB
Proteolysis Source: GOC

Cellular Location

Endoplasmic reticulum membrane

Involvement in disease

Glycosylphosphatidylinositol biosynthesis defect 15 (GPIBD15):
An autosomal recessive disorder characterized by delayed psychomotor development, variable intellectual disability, hypotonia, early-onset seizures in most patients, and cerebellar atrophy, resulting in cerebellar signs including gait ataxia and dysarthria.

Topology

Cytoplasmic: 2-24
Helical: 25-45
Lumenal: 46-368
Helical: 369-389
Cytoplasmic: 390-427
Helical: 428-448
Lumenal: 449-458
Helical: 459-479
Cytoplasmic: 480-495
Helical: 496-516
Lumenal: 517-543
Helical: 544-564
Cytoplasmic: 565-599
Helical: 600-620
Lumenal: 621

Anti-GPAA1 antibodies

Mouse Anti-GPAA1 Recombinant Antibody (CBFYH-0432) (CBMAB-H1304-FY)

Datasheet

SDS

Target: GPAA1

Host: Mouse

Specificity: Mouse, Rat, Human

Clone: CBFYH-0432

Application*: WB, IP, IF, E

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)