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Mouse Anti-GPAA1 Recombinant Antibody (CBFYH-0432) (CBMAB-H1304-FY)

This product is mouse antibody that recognizes GPAA1. The antibody CBFYH-0432 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all GPAA1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
CBFYH-0432
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Glycosylphosphatidylinositol Anchor Attachment 1
Introduction
GPAA1 gene was frequently amplified (73%, 11/15) using quantitative microsatellite analysis.
Entrez Gene ID
Human8733
Mouse14731
Rat300046
UniProt ID
HumanO43292
MouseQ9WTK3
RatQ6AYM8
Alternative Names
Glycosylphosphatidylinositol Anchor Attachment 1; Anchor Attachment Protein 1 (Gaa1p, Yeast) Homolog; GPI Anchor Attachment Protein 1; GPI Transamidase Subunit; GAA1 Protein Homolog; HGAA1; GAA1; Glycosylphosphatidylinositol Anchor Attachment Protein 1 Homolog (Yeast)
Function
Essential for GPI-anchoring of precursor proteins but not for GPI synthesis. Acts before or during formation of the carbonyl intermediate.
Biological Process
Attachment of GPI anchor to protein Source: GO_Central
Protein-containing complex assembly Source: UniProtKB
Protein retention in ER lumen Source: UniProtKB
Proteolysis Source: GOC
Cellular Location
Endoplasmic reticulum membrane
Involvement in disease
Glycosylphosphatidylinositol biosynthesis defect 15 (GPIBD15):
An autosomal recessive disorder characterized by delayed psychomotor development, variable intellectual disability, hypotonia, early-onset seizures in most patients, and cerebellar atrophy, resulting in cerebellar signs including gait ataxia and dysarthria.
Topology
Cytoplasmic: 2-24
Helical: 25-45
Lumenal: 46-368
Helical: 369-389
Cytoplasmic: 390-427
Helical: 428-448
Lumenal: 449-458
Helical: 459-479
Cytoplasmic: 480-495
Helical: 496-516
Lumenal: 517-543
Helical: 544-564
Cytoplasmic: 565-599
Helical: 600-620
Lumenal: 621
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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