GPHA2

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]
Full Name
Glycoprotein Hormone Alpha 2
Function
Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258).

Plays a central role in controlling thyroid cell metabolism (PubMed:12045258).
Biological Process
Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB
Cellular Location
Secreted
PTM
Glycosylated.
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Anti-GPHA2 antibodies

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Human Recombinant GPHA2 protein, Fc Tag (V2LY-0526-LY4390)

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Target: GPHA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-129
Tag: Fc Tag
Datasheet SDS

Human Recombinant GPHA2 protein, His Tag (V2LY-0526-LY4389)

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Target: GPHA2
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-129
Tag: His Tag
Datasheet SDS

Mouse Anti-GPHA2 Recombinant Antibody (CBYJT-1291) (V2LY-0226-LY726)

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Target: GPHA2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYJT-1291
Application*: E
Datasheet SDS

Rabbit Anti-GPHA2 Recombinant Antibody (3F313) (V2LY-0226-LY725)

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Target: GPHA2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 3F313
Application*: E
Datasheet SDS

Mouse Anti-GPHA2 Recombinant Antibody (CBLG1-1608) (CBMAB-G4544-LY)

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Target: GPHA2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: CBLG1-1608
Application*: E, IP, IF, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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