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GPHA2

GPHA2 is a cystine knot-forming polypeptide and a subunit of the dimeric glycoprotein hormone family (Hsu et al., 2002 [PubMed 12089349]).[supplied by OMIM, Mar 2008]

Full Name

Glycoprotein Hormone Alpha 2

Function

Functions as a heterodimeric glycoprotein hormone with GPHB5 able to bind and activate the thyroid-stimulating hormone receptor (TSHR), leading to increased cAMP production (PubMed:12045258).

Plays a central role in controlling thyroid cell metabolism (PubMed:12045258).

Biological Process

Adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: UniProtKB
Cell surface receptor signaling pathway Source: UniProtKB

Cellular Location

Secreted

PTM

Glycosylated.

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Anti-GPHA2 antibodies

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Mouse Anti-GPHA2 Recombinant Antibody (CBYJT-1291) (V2LY-0226-LY726)

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Target: GPHA2

Host: Mouse

Antibody Isotype: IgG1

Specificity: Human

Clone: CBYJT-1291

Application*: E

Rabbit Anti-GPHA2 Recombinant Antibody (3F313) (V2LY-0226-LY725)

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Target: GPHA2

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: 3F313

Application*: E

Mouse Anti-GPHA2 Recombinant Antibody (CBLG1-1608) (CBMAB-G4544-LY)

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Target: GPHA2

Host: Mouse

Antibody Isotype: IgG1, κ

Specificity: Human, Mouse, Rat

Clone: CBLG1-1608

Application*: E, IP, IF, WB

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Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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