GPR132

This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Full Name

G Protein-Coupled Receptor 132

Function

May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.

Biological Process

G1/S transition of mitotic cell cycle Source: GO_Central
Negative regulation of G2/M transition of mitotic cell cycle Source: GO_Central

Cellular Location

Cell membrane. Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity).

Topology

Extracellular: 1-45
Helical: 46-68
Cytoplasmic: 69-79
Helical: 80-102
Extracellular: 103-116
Helical: 117-138
Cytoplasmic: 139-158
Helical: 159-178
Extracellular: 179-197
Helical: 198-220
Cytoplasmic: 221-246
Helical: 247-269
Extracellular: 270-288
Helical: 289-311
Cytoplasmic: 312-380