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Rabbit Anti-GPR132 Recombinant Antibody (EG1372) (CBMAB-EN1651-LY)

The product is antibody recognizes GPR132. The antibody EG1372 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:5000.
See all GPR132 antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1372
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:5000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human GPR132.
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
G Protein-Coupled Receptor 132
Introduction
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor (GPCR) superfamily. The receptors are seven-pass transmembrane proteins that respond to extracellular cues and activate intracellular signal transduction pathways. This protein was reported to be a receptor for lysophosphatidylcholine action, but PubMedID: 15653487 retracts this finding and instead suggests this protein to be an effector of lysophosphatidylcholine action. This protein may have proton-sensing activity and may be a receptor for oxidized free fatty acids. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Entrez Gene ID
29933
UniProt ID
Q9UNW8
Alternative Names
G Protein-Coupled Receptor 132; G2 Accumulation Protein; G2A; Probable G-Protein Coupled Receptor 132; G2 Accumulation;
Function
May be a receptor for oxidized free fatty acids derived from linoleic and arachidonic acids such as 9-hydroxyoctadecadienoic acid (9-HODE). Activates a G alpha protein, most likely G alpha(q). May be involved in apoptosis. Functions at the G2/M checkpoint to delay mitosis. May function as a sensor that monitors the oxidative states and mediates appropriate cellular responses such as secretion of paracrine signals and attenuation of proliferation. May mediate ths accumulation of intracellular inositol phosphates at acidic pH through proton-sensing activity.
Biological Process
G1/S transition of mitotic cell cycle Source: GO_Central
Negative regulation of G2/M transition of mitotic cell cycle Source: GO_Central
Cellular Location
Cell membrane. Internalized and accumulated in endosomal compartments. LPC triggers the relocalization from the endosomal compartment to the cell surface (By similarity).
Topology
Extracellular: 1-45
Helical: 46-68
Cytoplasmic: 69-79
Helical: 80-102
Extracellular: 103-116
Helical: 117-138
Cytoplasmic: 139-158
Helical: 159-178
Extracellular: 179-197
Helical: 198-220
Cytoplasmic: 221-246
Helical: 247-269
Extracellular: 270-288
Helical: 289-311
Cytoplasmic: 312-380
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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