GTF2A1L
The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]
Full Name
General Transcription Factor IIA Subunit 1 Like
Function
May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.
Biological Process
Cognition Source: UniProtKB
Transcription by RNA polymerase II Source: GO_Central
Transcription initiation from RNA polymerase II promoter Source: InterPro
Transcription by RNA polymerase II Source: GO_Central
Transcription initiation from RNA polymerase II promoter Source: InterPro
Cellular Location
Nucleus. Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
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Anti-GTF2A1L antibodies
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Target: GTF2A1L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2092
Application*: WB, E, IP, IF
Target: GTF2A1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 5B9
Application*: WB
Target: GTF2A1L
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2093
Application*: WB
Target: GTF2A1L
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6F5
Application*: E
Target: GTF2A1L
Specificity: Human
Target: GTF2A1L
Specificity: Human
Target: GTF2A1L
Specificity: Human
Target: GTF2A1L
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human, Rat, Mouse
Clone: 6F5
Application*: WB, E
Target: GTF2A1L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E3
Application*: WB, E, IP
Target: GTF2A1L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 5B9
Application*: WB, E, IP
Target: GTF2A1L
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-273
Application*: WB, E, IP
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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