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Mouse Anti-GTF2A1L Recombinant Antibody (5B9) (CBMAB-G5647-LY)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
5B9
Antibody Isotype
IgG2b, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa251-349 from human ALF (NP_006863) with GST tag. MW of the GST tag alone is 26kD
Specificity
Human, Rat
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
General Transcription Factor IIA Subunit 1 Like
Introduction
The assembly and stability of the RNA polymerase II transcription pre-initiation complex on a eukaryotic core promoter involve the effects of transcription factor IIA (TFIIA) on the interaction between TATA-binding protein (TBP) and DNA. This gene encodes a germ cell-specific counterpart of the large (alpha/beta) subunit of general transcription factor TFIIA that is able to stabilize the binding of TBP to DNA and may be uniquely important to testis biology. Alternative splicing for this locus has been observed and two variants, encoding distinct isoforms, have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (SALF), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Mar 2014]
Entrez Gene ID
Human11036
Rat316711
UniProt ID
HumanQ9UNN4
RatQ641W8
Alternative Names
General Transcription Factor IIA Subunit 1 Like; General Transcription Factor II A; 1-Like Factor; ALF; Testis Secretory Sperm-Binding Protein Li 230m; General Transcription Factor IIA; 1-Like; General Transcription Factor IIA 1 Like; General Transcription Factor IIA 1-Like;
Function
May function as a testis specific transcription factor. Binds DNA in conjunction with GTF2A2 and TBP (the TATA-binding protein) and together with GTF2A2, allows mRNA transcription.
Biological Process
Cognition Source: UniProtKB
Transcription by RNA polymerase II Source: GO_Central
Transcription initiation from RNA polymerase II promoter Source: InterPro
Cellular Location
Nucleus. Mainly localizes in the annulus and partly in acrosomal cap area of spermatozoa.
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For research use only. Not intended for any clinical use.

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