GUCY1B1

This gene encodes the beta subunit of the soluble guanylate cyclase (sGC), which catalyzes the conversion of GTP (guanosine triphosphate) to cGMP (cyclic guanosine monophosphate). The encoded protein contains an HNOX domain, which serves as a receptor for ligands such as nitric oxide, oxygen and nitrovasodilator drugs. Alternative splicing results in multiple transcript variants.

Full Name

Guanylate Cyclase 1 Soluble Subunit Beta 1

Function

Mediates responses to nitric oxide (NO) by catalyzing the biosynthesis of the signaling molecule cGMP.

Biological Process

Blood circulation Source: ProtInc
Cellular response to nitric oxide Source: UniProtKB
cGMP biosynthetic process Source: UniProtKB
cGMP-mediated signaling Source: GO_Central
Nitric oxide-cGMP-mediated signaling pathway Source: UniProtKB
Nitric oxide mediated signal transduction Source: ProtInc
Trans-synaptic signaling by nitric oxide, modulating synaptic transmission Source: GO_Central

Cellular Location

Cytoplasm

Anti-GUCY1B1 antibodies

Mouse Anti-GUCY1B1 Recombinant Antibody (GC11) (CBMAB-G5780-LY)

Datasheet

SDS

Target: GUCY1B1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: GC11

Application*: WB

Mouse Anti-GUCY1B1 Recombinant Antibody (G-3) (CBMAB-G5779-LY)

Datasheet

SDS

Target: GUCY1B1

Host: Mouse

Antibody Isotype: IgG

Specificity: Mouse, Rat, Human

Clone: G-3

Application*: WB

Rabbit Anti-GUCY1B1 Recombinant Antibody (CBLG1-3047) (CBMAB-G5778-LY)

Datasheet

SDS

Target: GUCY1B1

Host: Rabbit

Antibody Isotype: IgG

Specificity: Human

Clone: CBLG1-3047

Application*: WB

Mouse Anti-GUCY1B1 Recombinant Antibody (10C448) (CBMAB-G5776-LY)

Datasheet

SDS

Target: GUCY1B1

Host: Mouse

Antibody Isotype: IgG2b

Specificity: Human

Clone: 10C448

Application*: E, WB

More Infomation

For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

IFImmunofluorescence

IHImmunohistochemistry

IPImmunoprecipitation

WBWestern Blot

EELISA

MMicroarray

CIChromatin Immunoprecipitation

FFlow Cytometry

FNFunction Assay

IDImmunodiffusion

RRadioimmunoassay

TCTissue Culture

GSGel Supershift

NNeutralization

BBlocking

AActivation

IInhibition

DDepletion

ESELISpot

DBDot Blot

MCMass Cytometry/CyTOF

CTCytotoxicity

SStimulation

AGAgonist

APApoptosis

IMImmunomicroscopy

BABioassay

CSCostimulation

EMElectron Microscopy

IEImmunoelectrophoresis

PAPeptide Array

ICImmunocytochemistry

PEPeptide ELISA

MDMeDIP

SHIn situ hybridization

IAEnzyme Immunoassay

SEsandwich ELISA

PLProximity Ligation Assay

ECELISA(Cap)

EDELISA(Det)

BIBioimaging

IOImmunoassay

LFLateral Flow Immunoassay

LALuminex Assay

CImmunohistochemistry-Frozen Sections

PImmunohistologyp-Paraffin Sections

ISIntracellular Staining for Flow Cytometry

MSElectrophoretic Mobility Shift Assay

RIRNA Binding Protein Immunoprecipitation (RIP)