GYPA
Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]
Full Name
Glycophorin A (MNS Blood Group)
Function
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Cellular Location
Cell membrane. Appears to be colocalized with SLC4A1.
Topology
Extracellular: 20-91
Helical: 92-114
Cytoplasmic: 115-150
Helical: 92-114
Cytoplasmic: 115-150
PTM
The major O-linked glycan are NeuAc-alpha-2-3-Gal-beta-1-3-[NeuAc-alpha-2-6]-GalNAcOH (about 78 %) and NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-2-3-Gal-beta-1-3-[NeuAc-alpha-2-6]-GalNAcOH NeuAc-alpha-2-8-NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH-6-1-GlcNAc-beta-4-1-[Fuc-alpha-1-2]-Gal-beta-3-1-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH-6-1-GlcNAc-beta-4-1-[Fuc-alpha-1-2]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
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Anti-GYPA antibodies
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CompareTarget: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BRIC-256
Application*: IH, WB, FC
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3120
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: BRIC60
Application*: ELISA, WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: HIR2
Application*: ELISA, FC, IHC
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB229
Application*: IF, FC
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB228
Application*: IF, FC
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CB227
Application*: IF, FC
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-2994
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: CBFYH-2993
Application*: F, IF
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: IHC587
Application*: P, E, IH
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: HI264
Application*: E, WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 3H2003
Application*: FC, IH
Target: GYPA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Cattle
Clone: CBWJC-3752
Application*: C, IC, P
Target: GYPA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-3751
Application*: C, F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3749
Application*: E, C
Target: GYPA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human, Cattle
Clone: CBWJC-3748
Application*: C, IC, P
Target: GYPA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBWJC-2176
Application*: C
Target: GYPA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBFYM-1118
Application*: WB, IP, E, C, F
Target: GYPA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: 3H2005
Application*: F, IH
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2173
Application*: WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBLG1-2167
Application*: WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-2164
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-2163
Application*: WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: CBLG1-2162
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: NaM10-6G4
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: BRIC256
Application*: WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 143-13
Application*: IH, WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13H262
Application*: F
Target: GYPA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBLG1-289
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBLG1-288
Application*: WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBLG1-287
Application*: F
Target: GYPA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: YTH89.1
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SPM599
Application*: WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Cattle
Clone: SPM183
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: SGPA35
Application*: IF, P
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MM0314-7S41
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: GYPA/280
Application*: P
Target: GYPA
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: GYPA/1725R
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: GA-R2HIR2
Application*: C, P
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: ery-1-AME-1
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: E3
Application*: WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CMRF14
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Cattle
Clone: A63-C/A9
Application*: IF, IH
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5K247
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13H263
Application*: F
Target: GYPA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0548
Application*: F, IH
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-0546
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2995
Application*: F, IH, P
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: HI264
Application*: E, F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: GA-R2
Application*: C, P
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0549
Application*: WB
Target: GYPA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human
Clone: YTH 89.1
Application*: F, WB
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0547
Application*: WB, F, P, IF
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0550
Application*: F
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: JC159
Application*: F, IF, P
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-2992
Application*: F, P, IF, MC
Target: GYPA
Host: Rabbit
Antibody Isotype: IgG, κ
Specificity: Human
Clone: CBFYH-2991
Application*: F, IF, P, MC
Target: GYPA
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human, Cattle
Clone: GPHN02
Application*: F, IF, MC
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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