GYPA

Glycophorins A (GYPA) and B (GYPB) are major sialoglycoproteins of the human erythrocyte membrane which bear the antigenic determinants for the MN and Ss blood groups. In addition to the M or N and S or s antigens that commonly occur in all populations, about 40 related variant phenotypes have been identified. These variants include all the variants of the Miltenberger complex and several isoforms of Sta, as well as Dantu, Sat, He, Mg, and deletion variants Ena, S-s-U- and Mk. Most of the variants are the result of gene recombinations between GYPA and GYPB. [provided by RefSeq, Jul 2008]
Full Name
Glycophorin A (MNS Blood Group)
Function
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Cellular Location
Cell membrane. Appears to be colocalized with SLC4A1.
Topology
Extracellular: 20-91
Helical: 92-114
Cytoplasmic: 115-150
PTM
The major O-linked glycan are NeuAc-alpha-2-3-Gal-beta-1-3-[NeuAc-alpha-2-6]-GalNAcOH (about 78 %) and NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-2-3-Gal-beta-1-3-[NeuAc-alpha-2-6]-GalNAcOH NeuAc-alpha-2-8-NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH-6-1-GlcNAc-beta-4-1-[Fuc-alpha-1-2]-Gal-beta-3-1-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH-6-1-GlcNAc-beta-4-1-[Fuc-alpha-1-2]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
View more

Anti-GYPA antibodies

+ Filters
Loading...

Human Recombinant GYPA protein, His Tag (V2LY-0526-LY4338)

Go to compareCompare
Target: GYPA
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-91
Tag: His Tag
Datasheet SDS

Rabbit Anti-GYPA Recombinant Antibody (
27A8) (V2LY-0725-LY1124)

Go to compareCompare
Target: GYPA
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: 27A8
Application*: E, F
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBT3120
Application*: F
Datasheet SDS

Rat Anti-GYPA Recombinant Antibody (3H5) (CBMAB-C1220-LY)

Go to compareCompare
Target: GYPA
Host: Rat
Antibody Isotype: IgG2b, κ
Specificity: Mouse
Clone: 3H2
Application*: F, IH
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (CBLG1-2163) (CBMAB-G5843-LY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBLG1-2163
Application*: WB, P, IP, IF, F
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (6G4) (CBMAB-G5838-LY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 6G4
Application*: WB, P, IP, IF, F
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (256) (CBMAB-G5834-LY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat
Clone: 256
Application*: F, IH
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (13) (CBMAB-G5830-LY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 13
Application*: WB, E, IP, IF
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (89) (CBMAB-G0963-LY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgM, κ
Specificity: Human
Clone: 89
Application*: F, IF, WB, P
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (83) (CBMAB-G0961-LY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 83
Application*: IP, IF, WB, P
Datasheet SDS

Rat Anti-GYPA Recombinant Antibody (80) (CBMAB-G0955-LY)

Go to compareCompare
Target: GYPA
Host: Rat
Antibody Isotype: IgG2b
Specificity: Human, Mouse, Rat
Clone: 80
Application*: WB, IP, P, F
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (13H263) (CBMAB-G0943-LY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 13H263
Application*: WB, E, IH
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (64) (CBMAB-H1427-FY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 64
Application*: F
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (R2) (CBMAB-H1426-FY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: R2
Application*: WB, E
Datasheet SDS

Mouse Anti-GYPA Recombinant Antibody (2) (CBMAB-H0136-FY)

Go to compareCompare
Target: GYPA
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2
Application*: E, F
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

Hot products Hot products

For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
online inquiry
Online Inquiry

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.