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Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839)


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Tested Data
Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839) in ELISA
Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839) in ELISA
Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839) in WB
Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839) in WB
Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839) in WB
Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839) in WB
Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839) in FC
Mouse Anti-GYPA Recombinant Antibody (CBT3120) (V2LY-0625-LY1839) in FC

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBT3120
Antibody Isotype
IgG1
Application
FC

Basic Information

Immunogen
Purified recombinant fragment of human CD235a (AA: 20-91) expressed in E. Coli.
Host Species
Mouse
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal Antibody
Application Notes
ApplicationNote
WB1:500-1:2,000
FC1:200-1:400
ELISA1:10,000

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS
Preservative
Sodium azide
Concentration
Batch dependent
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Glycophorin A (MNS Blood Group)
Entrez Gene ID
2993
UniProt ID
P02724
Function
Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).
Cellular Location
Cell membrane. Appears to be colocalized with SLC4A1.
Topology
Extracellular: 20-91
Helical: 92-114
Cytoplasmic: 115-150
PTM
The major O-linked glycan are NeuAc-alpha-2-3-Gal-beta-1-3-[NeuAc-alpha-2-6]-GalNAcOH (about 78 %) and NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH (17 %). Minor O-glycans (5 %) include NeuAc-alpha-2-3-Gal-beta-1-3-[NeuAc-alpha-2-6]-GalNAcOH NeuAc-alpha-2-8-NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH. About 1% of all O-linked glycans carry blood group A, B and H determinants. They derive from a type-2 precursor core structure, Gal-beta-(1,3)-GlcNAc-beta-1-R, and the antigens are synthesized by addition of fucose (H antigen-specific) and then N-acetylgalactosamine (A antigen-specific) or galactose (B antigen-specific). Specifically O-linked-glycans are NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH-6-1-GlcNAc-beta-4-1-[Fuc-alpha-1-2]-Gal-beta-3-1-GalNAc-alpha (about 1%, B antigen-specific) and NeuAc-alpha-2-3-Gal-beta-1-3-GalNAcOH-6-1-GlcNAc-beta-4-1-[Fuc-alpha-1-2]-Gal-beta (1 %, O antigen-, A antigen- and B antigen-specific).
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For research use only. Not intended for any clinical use.

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