HACD3

HACD3 (3-Hydroxyacyl-CoA Dehydratase 3) is a protein coding gene. Among its related pathways are Fatty Acyl-CoA Biosynthesis and Fatty acid elongation. Gene Ontology annotations related to this gene include enzyme binding and lyase activity. An important paralog of the gene is HACD4.

Full Name

3-Hydroxyacyl-CoA Dehydratase 3

Function

Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).

Biological Process

Fatty acid elongation Source: UniProtKB
I-kappaB kinase/NF-kappaB signaling Source: ProtInc
JNK cascade Source: Ensembl
Positive regulation by virus of viral protein levels in host cell Source: AgBase
Positive regulation of viral genome replication Source: AgBase
Rac protein signal transduction Source: UniProtKB
Rho protein signal transduction Source: Ensembl
Small GTPase mediated signal transduction Source: ProtInc
Sphingolipid biosynthetic process Source: GO_Central
Very long-chain fatty acid biosynthetic process Source: UniProtKB

Cellular Location

Endoplasmic reticulum membrane

Topology

Cytoplasmic: 1-149
Helical: 150-170
Lumenal: 171-185
Helical: 186-207
Cytoplasmic: 208-217
Helical: 218-235
Lumenal: 236-241
Helical: 242-256
Cytoplasmic: 257-279
Helical: 280-298
Lumenal: 299-322
Helical: 323-343
Cytoplasmic: 344-362