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Mouse Anti-HACD3 Recombinant Antibody (5B5) (CBMAB-A7219-LY)

The product is antibody recognizes PTPLAD1. The antibody 5B5 immunoassay techniques such as: WB, ELISA.
See all HACD3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5B5
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
PTPLAD1 (NP_057479, 1 a.a. ~ 113 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
3-Hydroxyacyl-CoA Dehydratase 3
Entrez Gene ID
51495
UniProt ID
Q9P035
Alternative Names
B-IND1; FLJ90376; HSPC121
Function
Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May be involved in Rac1-signaling pathways leading to the modulation of gene expression. Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571).
Biological Process
Fatty acid elongation Source: UniProtKB
I-kappaB kinase/NF-kappaB signaling Source: ProtInc
JNK cascade Source: Ensembl
Positive regulation by virus of viral protein levels in host cell Source: AgBase
Positive regulation of viral genome replication Source: AgBase
Rac protein signal transduction Source: UniProtKB
Rho protein signal transduction Source: Ensembl
Small GTPase mediated signal transduction Source: ProtInc
Sphingolipid biosynthetic process Source: GO_Central
Very long-chain fatty acid biosynthetic process Source: UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Topology
Cytoplasmic: 1-149
Helical: 150-170
Lumenal: 171-185
Helical: 186-207
Cytoplasmic: 208-217
Helical: 218-235
Lumenal: 236-241
Helical: 242-256
Cytoplasmic: 257-279
Helical: 280-298
Lumenal: 299-322
Helical: 323-343
Cytoplasmic: 344-362
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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