HCLS1

HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1) is a Protein Coding gene. Diseases associated with HCLS1 include Spherocytosis, Type 1 and Congenital Hemolytic Anemia. Among its related pathways are Development Slit-Robo signaling and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is CTTN.

hematopoietic cell-specific Lyn substrate 1

Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.

Actin filament polymerization Source: InterPro
Cellular response to cytokine stimulus Source: BHF-UCL
Erythrocyte differentiation Source: UniProtKB
Intracellular signal transduction Source: ProtInc
Negative regulation of leukocyte apoptotic process Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of granulocyte differentiation Source: BHF-UCL
Positive regulation of macrophage differentiation Source: Ensembl
Positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein import into nucleus Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Regulation of actin filament polymerization Source: BHF-UCL
Regulation of transcription, DNA-templated Source: ProtInc
Response to hormone Source: UniProtKB

Mitochondrion; Cytoplasm; Membrane

Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES.