HCLS1

HCLS1 (Hematopoietic Cell-Specific Lyn Substrate 1) is a Protein Coding gene. Diseases associated with HCLS1 include Spherocytosis, Type 1 and Congenital Hemolytic Anemia. Among its related pathways are Development Slit-Robo signaling and Immune response Fc epsilon RI pathway. Gene Ontology (GO) annotations related to this gene include protein kinase binding and protein complex binding. An important paralog of this gene is CTTN.
Full Name
hematopoietic cell-specific Lyn substrate 1
Function
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Biological Process
Actin filament polymerization Source: InterPro
Cellular response to cytokine stimulus Source: BHF-UCL
Erythrocyte differentiation Source: UniProtKB
Intracellular signal transduction Source: ProtInc
Negative regulation of leukocyte apoptotic process Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of granulocyte differentiation Source: BHF-UCL
Positive regulation of macrophage differentiation Source: Ensembl
Positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein import into nucleus Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Regulation of actin filament polymerization Source: BHF-UCL
Regulation of transcription, DNA-templated Source: ProtInc
Response to hormone Source: UniProtKB
Cellular Location
Mitochondrion; Cytoplasm; Membrane
PTM
Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES.
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Anti-HCLS1 antibodies

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Target: HCLS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A8
Application*: WB, E
Target: HCLS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: D12C1
Application*: WB, IF, FC
Target: HCLS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYCL-122
Application*: E, WB
Target: HCLS1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBYJL-128
Application*: WB, IP, IF, E
Target: HCLS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: D5A9
Application*: WB, IP, P, IF, IF (IC), F
Target: HCLS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D83A8
Application*: WB, IP, P, IF (IC), F
Target: HCLS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Mouse, Rat
Clone: CBFYH-3539
Application*: WB, IP, P, F
Target: HCLS1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-0780
Application*: IP, WB
Target: HCLS1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0779
Application*: E, WB, P
Target: HCLS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0778
Application*: E, WB, P
Target: HCLS1
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-0777
Application*: PL, WB, SE, E, WB-Ce, P
Target: HCLS1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: D83A8
Application*: WB, IP, P, IF, F
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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