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Mouse Anti-HCLS1 Recombinant Antibody (1A8) (CBMAB-A3767-LY)

The product is antibody recognizes HCLS1. The antibody 1A8 immunoassay techniques such as: WB, ELISA.
See all HCLS1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1A8
Antibody Isotype
IgG1, κ
Application
WB, ELISA

Basic Information

Immunogen
HCLS1 (AAH16758, 266 a.a. ~ 355 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG1, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
hematopoietic cell-specific Lyn substrate 1
Entrez Gene ID
3059
UniProt ID
P14317
Alternative Names
CTTNL; HS1
Function
Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression.
Biological Process
Actin filament polymerization Source: InterPro
Cellular response to cytokine stimulus Source: BHF-UCL
Erythrocyte differentiation Source: UniProtKB
Intracellular signal transduction Source: ProtInc
Negative regulation of leukocyte apoptotic process Source: BHF-UCL
Negative regulation of transcription by RNA polymerase II Source: Ensembl
Positive regulation of actin cytoskeleton reorganization Source: BHF-UCL
Positive regulation of cell population proliferation Source: UniProtKB
Positive regulation of DNA-binding transcription factor activity Source: BHF-UCL
Positive regulation of granulocyte differentiation Source: BHF-UCL
Positive regulation of macrophage differentiation Source: Ensembl
Positive regulation of peptidyl-serine phosphorylation Source: BHF-UCL
Positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
Positive regulation of phosphatidylinositol 3-kinase signaling Source: BHF-UCL
Positive regulation of protein import into nucleus Source: BHF-UCL
Positive regulation of protein kinase B signaling Source: BHF-UCL
Positive regulation of transcription by RNA polymerase II Source: BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein Source: UniProtKB
Regulation of actin filament polymerization Source: BHF-UCL
Regulation of transcription, DNA-templated Source: ProtInc
Response to hormone Source: UniProtKB
Cellular Location
Mitochondrion; Cytoplasm; Membrane
PTM
Phosphorylated by FES (By similarity). Phosphorylated by LYN, FYN and FGR after cross-linking of surface IgM on B-cells. Phosphorylation by LYN, FYN and FGR requires prior phosphorylation by SYK or FES.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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