HEXIM1

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
Full Name
HEXIM P-TEFb complex subunit 1
Function
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869).

Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869).

May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550).

Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Biological Process
Activation of innate immune response Source: UniProtKB
Heart development Source: Ensembl
Innate immune response Source: UniProtKB-KW
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC-UCL
Negative regulation of transcription, DNA-templated Source: HGNC-UCL
Negative regulation of transcription by RNA polymerase II Source: HGNC-UCL
Negative regulation of transcription elongation from RNA polymerase II promoter Source: FlyBase
Negative regulation of viral transcription Source: FlyBase
Positive regulation of signal transduction by p53 class mediator Source: CACAO
Cellular Location
Nucleus; Cytoplasm. Binds alpha-importin and is mostly nuclear (PubMed:16362050).
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Anti-HEXIM1 antibodies

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Human HEXIM1 ELISA Kit (V2LY-0626-LY5100)

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Target: HEXIM1
Sensitivity: 0.0096 ng/mL
Detection Range: 0.02-4.5 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Human
Assay Type: Sandwich
Reactivity: Human
Datasheet SDS

Mouse Hexim1 ELISA Kit (V2LY-0626-LY2927)

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Target: Hexim1
Sensitivity: 0.0016 ng/mL
Detection Range: 0.003-0.9 ng/mL
Sample Type: Serum, Plasma, cell culture supernates
Specificity: Mouse
Assay Type: Sandwich
Reactivity: Mouse
Datasheet SDS

Rabbit Anti-HEXIM1 Recombinant Antibody (EG1508) (CBMAB-EN1802-LY)

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Target: HEXIM1
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: EG1508
Application*: WB: 1:500~1:1000 IF: 1:100~1:500 ELISA: 1:10000
Datasheet SDS

Mouse Anti-HEXIM1 Recombinant Antibody (A162) (CBMAB-AP9630LY)

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Target: HEXIM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: A162
Application*: ELISA, WB
Datasheet SDS

Mouse Anti-HEXIM1 Recombinant Antibody (4G4) (CBMAB-A3848-LY)

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Target: HEXIM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: 4G4
Application*: WB, E
Datasheet SDS

Mouse Anti-HEXIM1 Recombinant Antibody (2D12) (CBMAB-A3847-LY)

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Target: HEXIM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 2D12
Application*: IH, E
Datasheet SDS

Mouse Anti-HEXIM1 Recombinant Antibody (1H5) (CBMAB-A3846-LY)

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Target: HEXIM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 1H5
Application*: WB, E
Datasheet SDS

Mouse Anti-HEXIM1 (AA 1-359) Recombinant Antibody (CBFYH-0982) (CBMAB-H1923-FY)

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Target: HEXIM1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: CBFYH-0982
Application*: E, IF, WB
Datasheet SDS

Mouse Anti-HEXIM1 Recombinant Antibody (CBFYH-0981) (CBMAB-H1922-FY)

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Target: HEXIM1
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-0981
Application*: E, P, WB
Datasheet SDS

Mouse Anti-HEXIM1 Recombinant Antibody (2C8A2) (CBMAB-H1921-FY)

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Target: HEXIM1
Host: Mouse
Antibody Isotype: IgM
Specificity: Human
Clone: 2C8A2
Application*: E, WB
Datasheet SDS

Mouse Anti-HEXIM1 Monoclonal Antibody (CBFYH-3054) (CBMAB-H1920-FY)

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Target: HEXIM1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-3054
Application*: DB, IC, IF, WB
Datasheet SDS

Rabbit Anti-HEXIM1 Recombinant Antibody (D5Y5K) (CBMAB-H0781-FY)

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Target: HEXIM1
Host: Rabbit
Specificity: Human, Monkey
Clone: D5Y5K
Application*: WB, IP, IF, F
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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