HEXIM1

Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.

HEXIM P-TEFb complex subunit 1

Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869).

Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869).

May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550).

Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).

Activation of innate immune response Source: UniProtKB
Heart development Source: Ensembl
Innate immune response Source: UniProtKB-KW
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC-UCL
Negative regulation of transcription, DNA-templated Source: HGNC-UCL
Negative regulation of transcription by RNA polymerase II Source: HGNC-UCL
Negative regulation of transcription elongation from RNA polymerase II promoter Source: FlyBase
Negative regulation of viral transcription Source: FlyBase
Positive regulation of signal transduction by p53 class mediator Source: CACAO

Nucleus; Cytoplasm. Binds alpha-importin and is mostly nuclear (PubMed:16362050).