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Rabbit Anti-HEXIM1 Recombinant Antibody (D5Y5K) (CBMAB-H0781-FY)

This product is rabbit antibody that recognizes HEXIM1. The antibody D5Y5K can be used for immunoassay techniques such as: WB, IP, IF, FC.
See all HEXIM1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Monkey
Clone
D5Y5K
Application
WB, IP, IF, FC

Basic Information

Specificity
Human, Monkey
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
HEXIM P-TEFb complex subunit 1
Introduction
Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns.
Entrez Gene ID
Human10614
Monkey716006
UniProt ID
HumanO94992
MonkeyF7BGX2
Alternative Names
Hexamethylene Bisacetamide Inducible 1; Hexamethylene Bis-Acetamide-Inducible Protein 1; Estrogen Down-Regulated Gene 1 Protein; Cardiac Lineage Protein 1; Menage A Quatre Protein 1; CLP1; EDG1; HIS1; MAQ1
Function
Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor (PubMed:14580347, PubMed:15713661, PubMed:15201869).

Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869).

May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550).

Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Biological Process
Activation of innate immune response Source: UniProtKB
Heart development Source: Ensembl
Innate immune response Source: UniProtKB-KW
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC-UCL
Negative regulation of transcription, DNA-templated Source: HGNC-UCL
Negative regulation of transcription by RNA polymerase II Source: HGNC-UCL
Negative regulation of transcription elongation from RNA polymerase II promoter Source: FlyBase
Negative regulation of viral transcription Source: FlyBase
Positive regulation of signal transduction by p53 class mediator Source: CACAO
Cellular Location
Nucleus; Cytoplasm. Binds alpha-importin and is mostly nuclear (PubMed:16362050).

Lloyd, S. M., Leon, D. B., Brady, M. O., Rodriguez, D., McReynolds, M. P., Kweon, J., ... & Bao, X. (2022). CDK9 activity switch associated with AFF1 and HEXIM1 controls differentiation initiation from epidermal progenitors. Nature communications, 13(1), 4408.

Mozar, F., Sharma, V., Gorityala, S., Albert, J. M., Xu, Y., & Montano, M. M. (2022). Downregulation of Dihydrotestosterone and Estradiol Levels by HEXIM1. Endocrinology, 163(1), bqab236.

Chen, G., Li, Y., Kong, X., Zhao, S., Li, J., & Wu, X. (2022). Overexpression Bombyx mori HEXIM1 Facilitates Immune Escape of Bombyx mori Nucleopolyhedrovirus by Suppressing BmRelish-Driven Immune Responses. Viruses, 14(12), 2636.

Liu, Y., Li, L., Timani, K., White, C., & He, J. J. (2021). Tip110 Expression Facilitates the Release of HEXIM1 and pTEFb from the 7SK Ribonucleoprotein Complex Involving Regulation of the Intracellular Redox Level. Aging and disease, 12(8), 2113.

Shao, H., Zhu, Q., Lu, H., Chang, A., Gao, C., Zhou, Q., & Luo, K. (2020). HEXIM1 controls P-TEFb processing and regulates drug sensitivity in triple-negative breast cancer. Molecular biology of the cell, 31(17), 1867-1878.

Montano, M. M., Yeh, I. J., Chen, Y., Hernandez, C., Kiselar, J. G., de la Fuente, M., ... & Lawes, M. C. (2019). Inhibition of the histone demethylase, KDM5B, directly induces re-expression of tumor suppressor protein HEXIM1 in cancer cells. Breast Cancer Research, 21, 1-15.

Leoz, M., Kukanja, P., Luo, Z., Huang, F., Cary, D. C., Peterlin, B. M., & Fujinaga, K. (2018). HEXIM1-Tat chimera inhibits HIV-1 replication. PLoS Pathogens, 14(11), e1007402.

Bowry, A., Piberger, A. L., Rojas, P., Saponaro, M., & Petermann, E. (2018). BET inhibition induces HEXIM1-and RAD51-dependent conflicts between transcription and replication. Cell reports, 25(8), 2061-2069.

Michels, A. A., & Bensaude, O. (2018). Hexim1, an RNA-controlled protein hub. Transcription, 9(4), 262-271.

Ho, P. L., Ong, H. K., Teo, J., Ow, D. S. W., & Chao, S. H. (2019). HEXIM1 peptide exhibits antimicrobial activity against antibiotic resistant bacteria through guidance of cell penetrating peptide. Frontiers in microbiology, 10, 203.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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