Rabbit Anti-HEXIM1 Recombinant Antibody (D5Y5K) (CBMAB-H0781-FY)
Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Core component of the 7SK RNP complex: in cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation (PubMed:12832472, PubMed:14580347, PubMed:15713661, PubMed:15201869).
May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity (PubMed:15940264, PubMed:15941832, PubMed:17088550).
Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway (PubMed:28712728).
Heart development Source: Ensembl
Innate immune response Source: UniProtKB-KW
Negative regulation of cyclin-dependent protein serine/threonine kinase activity Source: HGNC-UCL
Negative regulation of transcription, DNA-templated Source: HGNC-UCL
Negative regulation of transcription by RNA polymerase II Source: HGNC-UCL
Negative regulation of transcription elongation from RNA polymerase II promoter Source: FlyBase
Negative regulation of viral transcription Source: FlyBase
Positive regulation of signal transduction by p53 class mediator Source: CACAO
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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