HINT2
Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM
Full Name
histidine triad nucleotide binding protein 2
Function
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367).
Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638).
Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367).
May be involved in steroid biosynthesis (PubMed:18653718).
May play a role in apoptosis (PubMed:16762638).
Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638).
Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367).
May be involved in steroid biosynthesis (PubMed:18653718).
May play a role in apoptosis (PubMed:16762638).
Biological Process
Apoptotic process Source: UniProtKB-KW
Lipid catabolic process Source: Ensembl
Negative regulation of peptidyl-lysine acetylation Source: Ensembl
Steroid biosynthetic process Source: UniProtKB-KW
Lipid catabolic process Source: Ensembl
Negative regulation of peptidyl-lysine acetylation Source: Ensembl
Steroid biosynthetic process Source: UniProtKB-KW
Cellular Location
Mitochondrion
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Anti-HINT2 antibodies
+ Filters
Target: HINT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: 4E11
Application*: WB, E
Target: HINT2
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBFYH-1113
Application*: WB
Target: HINT2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: CBFYH-1112
Application*: WB, F, E, IF
Target: HINT2
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human
Clone: CBFYH-1111
Application*: E, WB
Target: HINT2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: AT5B10
Application*: E, F, WB
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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