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  • Mouse Anti-HINT2 Recombinant Antibody (4E11)

Mouse Anti-HINT2 Recombinant Antibody (4E11) (CBMAB-A3901-LY)

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Datasheet
SDS
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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal
Mouse
Clone
4E11
Application
WB, ELISA
Immunogen
HINT2 (NP_115982, 60 a.a. ~ 163 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.
More Infomation

Target

Full Name
histidine triad nucleotide binding protein 2
Introduction
Histidine triad proteins, such as HINT2, are nucleotide hydrolases and transferases that act on the alpha-phosphate of ribonucleotides (Brenner, 2002 [PubMed 12119013]).[supplied by OMIM
Entrez Gene ID
84681
UniProt ID
Q9BX68
Alternative Names
HIT-17
Function
Exhibits adenosine 5'-monophosphoramidase activity, hydrolyzing purine nucleotide phosphoramidates with a single phosphate group such as adenosine 5'monophosphoramidate (AMP-NH2) to yield AMP and NH2 (PubMed:16762638, PubMed:31990367).

Hydrolyzes adenosine 5'-O-p-nitrophenylphosphoramidate (AMP-pNA) (PubMed:16762638).

Hydrolyzes fluorogenic purine nucleoside tryptamine phosphoramidates in vitro (PubMed:31990367).

May be involved in steroid biosynthesis (PubMed:18653718).

May play a role in apoptosis (PubMed:16762638).
Biological Process
Apoptotic process Source: UniProtKB-KW
Lipid catabolic process Source: Ensembl
Negative regulation of peptidyl-lysine acetylation Source: Ensembl
Steroid biosynthetic process Source: UniProtKB-KW
Cellular Location
Mitochondrion

Li, F., Li, J., Hao, J., Liu, J., Zu, X., Li, S., & Wang, B. (2023). HINT2 deficiency deteriorates oxidative stress in a mouse model of myocardial infarction. ESC Heart Failure, 10(2), 1305-1313.

Di, W., Li, X., & Yang, Q. (2022). Polysaccharide of Lactobacillus casei SB27 reduced colon cancer cell prognosis through mitochondrial damage by upregulation of HINT2. Asia‐Pacific Journal of Clinical Oncology.

Li, S., Chen, J., Liu, M., Chen, Y., Wu, Y., Li, Q., ... & Ge, J. (2021). Protective effect of HINT2 on mitochondrial function via repressing MCU complex activation attenuates cardiac microvascular ischemia–reperfusion injury. Basic research in cardiology, 116(1), 65.

Strom, A., Tong, C. L., & Wagner, C. R. (2020). Histidine triad nucleotide‐binding proteins HINT1 and HINT2 share similar substrate specificities and little affinity for the signaling dinucleotide Ap4A. FEBS letters, 594(10), 1497-1505.

Zhou, D. K., Qian, X. H., Cheng, J., Chen, L. H., & Wang, W. L. (2019). Clinical significance of down-regulated HINT2 in hepatocellular carcinoma. Medicine, 98(48).

Jia, R., Chai, P., Wang, S., Sun, B., Xu, Y., Yang, Y., ... & Fan, X. (2019). m6A modification suppresses ocular melanoma through modulating HINT2 mRNA translation. Molecular cancer, 18(1), 1-21.

Fleming, J., Hernandez, G., Hartman, L., Maksimovic, J., Nace, S., Lawler, B., ... & Fabry, Z. (2019). Safety and efficacy of helminth treatment in relapsing-remitting multiple sclerosis: results of the HINT 2 clinical trial. Multiple Sclerosis Journal, 25(1), 81-91.

Rajasekaran, R., Felser, A., Nuoffer, J. M., Dufour, J. F., & St-Pierre, M. V. (2018). The histidine triad nucleotide‐binding protein 2 (HINT‐2) positively regulates hepatocellular energy metabolism. The FASEB Journal, 32(9), 5143-5161.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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