HOXA5

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis.

homeobox A5

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Anterior/posterior pattern specification Source: GO_Central
Bronchiole development Source: Ensembl
Cell-cell signaling involved in mammary gland development Source: Ensembl
Cell migration Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Intestinal epithelial cell maturation Source: Ensembl
Lung alveolus development Source: Ensembl
Lung-associated mesenchyme development Source: Ensembl
Lung goblet cell differentiation Source: Ensembl
Mammary gland alveolus development Source: Ensembl
Mammary gland epithelial cell differentiation Source: Ensembl
Mesenchymal-epithelial cell signaling Source: Ensembl
Multicellular organism growth Source: Ensembl
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of erythrocyte differentiation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of myeloid cell differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of mammary gland epithelial cell proliferation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Respiratory system process Source: Ensembl
Thyroid gland development Source: Ensembl
Trachea cartilage morphogenesis Source: Ensembl

Nucleus