Mouse Anti-HOXA5 Recombinant Antibody (3E8) (CBMAB-A4015-LY)

Name: Mouse Anti-HOXA5 Recombinant Antibody (3E8)
SKU: CBMAB-A4015-LY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

3E8

Application

WB, ELISA

Immunogen

HOXA5 (NP_061975.1, 171 a.a. ~ 270 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.

Specificity

Human

Antibody Isotype

IgG2b, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

> 95% Purity determined by SDS-PAGE.

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

homeobox A5

Introduction

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Methylation of this gene may result in the loss of its expression and, since the encoded protein upregulates the tumor suppressor p53, this protein may play an important role in tumorigenesis. [provided by RefSeq]

Entrez Gene ID

3202

UniProt ID

P20719

Alternative Names

HOX1; HOX1.3; HOX1C; MGC9376

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Also binds to its own promoter. Binds specifically to the motif 5'-CYYNATTA[TG]Y-3'.

Biological Process

Anterior/posterior pattern specification Source: GO_Central
Bronchiole development Source: Ensembl
Cell-cell signaling involved in mammary gland development Source: Ensembl
Cell migration Source: Ensembl
Embryonic skeletal system morphogenesis Source: Ensembl
Epithelial tube branching involved in lung morphogenesis Source: Ensembl
Intestinal epithelial cell maturation Source: Ensembl
Lung alveolus development Source: Ensembl
Lung-associated mesenchyme development Source: Ensembl
Lung goblet cell differentiation Source: Ensembl
Mammary gland alveolus development Source: Ensembl
Mammary gland epithelial cell differentiation Source: Ensembl
Mesenchymal-epithelial cell signaling Source: Ensembl
Multicellular organism growth Source: Ensembl
Negative regulation of angiogenesis Source: UniProtKB
Negative regulation of erythrocyte differentiation Source: UniProtKB
Positive regulation of apoptotic process Source: UniProtKB
Positive regulation of gene expression Source: UniProtKB
Positive regulation of myeloid cell differentiation Source: UniProtKB
Positive regulation of transcription by RNA polymerase II Source: UniProtKB
Regulation of mammary gland epithelial cell proliferation Source: Ensembl
Regulation of transcription by RNA polymerase II Source: GO_Central
Respiratory system process Source: Ensembl
Thyroid gland development Source: Ensembl
Trachea cartilage morphogenesis Source: Ensembl

Cellular Location

Nucleus

Fan, F., Mo, H., Zhang, H., Dai, Z., Wang, Z., Qu, C., ... & Ding, F. (2022). HOXA5: A crucial transcriptional factor in cancer and a potential therapeutic target. Biomedicine & Pharmacotherapy, 155, 113800.

Liang, Y., Cen, J., Huang, Y., Fang, Y., Wang, Y., Shu, G., ... & Zhang, J. (2022). CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug. Molecular Cancer, 21(1), 1-19.

Liang, Y., Zhou, R., Fu, X., Wang, C., & Wang, D. (2021). HOXA5 counteracts the function of pathological scar-derived fibroblasts by partially activating p53 signaling. Cell death & disease, 12(1), 40.

Ma, H. M., Cui, N., & Zheng, P. S. (2020). HOXA5 inhibits the proliferation and neoplasia of cervical cancer cells via downregulating the activity of the Wnt/β-catenin pathway and transactivating TP53. Cell Death & Disease, 11(6), 420.

Wang, H., Wei, H., Wang, J., Li, L., Chen, A., & Li, Z. (2020). MicroRNA-181d-5p-containing exosomes derived from CAFs promote EMT by regulating CDX2/HOXA5 in breast cancer. Molecular Therapy-Nucleic Acids, 19, 654-667.

Liao, Y., Wang, C., Yang, Z., Liu, W., Yuan, Y., Li, K., ... & Li, B. (2020). Dysregulated Sp1/miR-130b-3p/HOXA5 axis contributes to tumor angiogenesis and progression of hepatocellular carcinoma. Theranostics, 10(12), 5209.

Li, D., Bai, Y., Feng, Z., Li, W., Yang, C., Guo, Y., ... & Li, X. (2019). Study of promoter methylation patterns of HOXA2, HOXA5, and HOXA6 and its clinicopathological characteristics in colorectal cancer. Frontiers in oncology, 9, 394.

Wu, Y., Zhou, T., Tang, Q., & Xiao, J. (2019). HOXA5 inhibits tumor growth of gastric cancer under the regulation of microRNA-196a. Gene, 681, 62-68.

Peng, X., Zha, L., Chen, A., & Wang, Z. (2018). HOXA5 is a tumor suppressor gene that is decreased in gastric cancer. Oncology reports, 40(3), 1317-1329.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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