HPV-16 E2

Human papillomavirus infection is an infection by human papillomavirus (HPV).
Full Name
Human Papillomavirus Type 16 Regulatory Protein E2
Function
Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.
Biological Process
DNA replication Source: UniProtKB-KW
Regulation of DNA replication Source: UniProtKB-UniRule
Transcription, DNA-templated Source: UniProtKB-UniRule
Viral DNA genome replication Source: UniProtKB-UniRule
Cellular Location
Host nucleus
PTM
Phosphorylated. Phosphorylation at Ser-243 mediates binding to host Brd4 and is required for host chromosome binding.
Sumoylation plays a regulatory role in E2 transcriptional activity.
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Anti-HPV-16 E2 antibodies

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Mouse Anti-HPV-16 E2 Recombinant Antibody (CBMW-H0224) (CBMAB-V208-0249-FY)

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Target: HPV-16 E2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: HPV
Clone: CBMW-H0224
Application*: E, R, WB
Datasheet SDS

Mouse Anti-HPV-16 E2 Recombinant Antibody (CBMW-H0135) (CBMAB-V208-0155-FY)

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Target: HPV-16 E2
Host: Mouse
Antibody Isotype: IgG1
Specificity: HPV
Clone: CBMW-H0135
Application*: WB, E
Datasheet SDS

Mouse Anti-HPV-16 E2 Recombinant Antibody (CBMW-H0111) (CBMAB-V208-0129-FY)

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Target: HPV-16 E2
Host: Mouse
Antibody Isotype: IgG1
Specificity: HPV
Clone: CBMW-H0111
Application*: WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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