Mouse Anti-HPV-16 E2 Recombinant Antibody (CBMW-H0224) (CBMAB-V208-0249-FY)

Name: Mouse Anti-HPV-16 E2 Recombinant Antibody (CBMW-H0224)
SKU: CBMAB-V208-0249-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBMW-H0224

Application

ELISA, RIA, WB

Immunogen

HPV-16, E2 fusion protein

Specificity

HPV

Antibody Isotype

IgG1, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at-20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Human Papillomavirus Type 16 Regulatory Protein E2

Introduction

Human papillomavirus infection is an infection by human papillomavirus (HPV).

Entrez Gene ID

1489080

UniProt ID

P03120

Alternative Names

HPV-16 E2; Human papillomavirus type 16 Regulatory protein E2; HPV-16; Human papillomavirus type 16; Regulatory protein E2; E2

Function

Plays a role in the initiation of viral DNA replication. A dimer of E2 interacts with a dimer of E1 in order to improve specificity of E1 DNA binding activity. Once the complex recognizes and binds DNA at specific sites, the E2 dimer is removed from DNA. E2 also regulates viral transcription through binding to the E2RE response element (5'-ACCNNNNNNGGT-3') present in multiple copies in the regulatory regions of the viral genome. Activates or represses transcription depending on E2RE's position with regards to proximal promoter elements including the TATA-box. Repression occurs by sterically hindering the assembly of the transcription initiation complex.

Biological Process

DNA replication Source: UniProtKB-KW
Regulation of DNA replication Source: UniProtKB-UniRule
Transcription, DNA-templated Source: UniProtKB-UniRule
Viral DNA genome replication Source: UniProtKB-UniRule

Cellular Location

Host nucleus

PTM

Phosphorylated. Phosphorylation at Ser-243 mediates binding to host Brd4 and is required for host chromosome binding.
Sumoylation plays a regulatory role in E2 transcriptional activity.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-HPV-16 E2 Recombinant Antibody (CBMW-H0111) (CAT#: CBMAB-V208-0129-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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