HSPA2

HSPA2 (Heat Shock Protein Family A (Hsp70) Member 2) is a Protein Coding gene. Diseases associated with HSPA2 include Inflammatory Bowel Disease 3 and Papillary Cystadenocarcinoma. Among its related pathways are Meiosis and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and glycolipid binding. An important paralog of this gene is HSPA8.

Heat Shock Protein Family A (Hsp70) Member 2

Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release (PubMed:26865365).

Plays a role in spermatogenesis. In association with SHCBP1L may participate in the maintenance of spindle integrity during meiosis in male germ cells (By similarity).

Cellular response to unfolded protein Source: GO_Central
Chaperone cofactor-dependent protein refolding Source: GO_Central
Male meiosis I Source: Ensembl
Male meiotic nuclear division Source: ProtInc
Negative regulation of inclusion body assembly Source: UniProtKB
Positive regulation of ATPase activity Source: Ensembl
Positive regulation of ATPase-coupled calcium transmembrane transporter activity Source: Ensembl
Positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
Positive regulation of protein phosphorylation Source: Ensembl
Protein refolding Source: UniProtKB
Response to cold Source: AgBase
Response to heat Source: AgBase
Response to unfolded protein Source: ProtInc
Spermatid development Source: ProtInc
Spermatogenesis Source: UniProtKB
Synaptonemal complex disassembly Source: Ensembl
Vesicle-mediated transport Source: GO_Central

Spindle. Colocalizes with SHCBP1L at spindle during the meiosis process.