Mouse Anti-HSPA2 Recombinant Antibody (A297) (CBMAB-AP10555LY)

Name: Mouse Anti-HSPA2 Recombinant Antibody (A297)
SKU: CBMAB-AP10555LY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

A297

Application

ELISA, IF, IHC, WB

Immunogen

Fusion protein of HSPA2

Specificity

Human, Mouse, Rat

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Heat Shock Protein Family A (Hsp70) Member 2

Introduction

HSPA2 (Heat Shock Protein Family A (Hsp70) Member 2) is a Protein Coding gene. Diseases associated with HSPA2 include Inflammatory Bowel Disease 3 and Papillary Cystadenocarcinoma. Among its related pathways are Meiosis and MAPK signaling pathway. Gene Ontology (GO) annotations related to this gene include enzyme binding and glycolipid binding. An important paralog of this gene is HSPA8.

Entrez Gene ID

Human	3306
Mouse	15512
Rat	60460

UniProt ID

Human	P54652
Mouse	P17156
Rat	P14659

Alternative Names

Heat Shock Protein Family A (Hsp70) Member 2; Heat Shock 70kDa Protein 2; Heat Shock 70kD Protein 2; Heat Shock-Related 70 KDa Protein 2; Heat Shock 70 KDa Protein 2; HSP70-2; HSP70-3;

Function

E-AB-27192

Biological Process

Cellular response to unfolded protein Source: GO_Central
Chaperone cofactor-dependent protein refolding Source: GO_Central
Male meiosis I Source: Ensembl
Male meiotic nuclear division Source: ProtInc
Negative regulation of inclusion body assembly Source: UniProtKB
Positive regulation of ATPase activity Source: Ensembl
Positive regulation of ATPase-coupled calcium transmembrane transporter activity Source: Ensembl
Positive regulation of G2/M transition of mitotic cell cycle Source: Ensembl
Positive regulation of protein phosphorylation Source: Ensembl
Protein refolding Source: UniProtKB
Response to cold Source: AgBase
Response to heat Source: AgBase
Response to unfolded protein Source: ProtInc
Spermatid development Source: ProtInc
Spermatogenesis Source: UniProtKB
Synaptonemal complex disassembly Source: Ensembl
Vesicle-mediated transport Source: GO_Central

Cellular Location

Spindle. Colocalizes with SHCBP1L at spindle during the meiosis process.

Nowicka-Bauer, K., Malcher, A., Włoczkowska, O., Kamieniczna, M., Olszewska, M., & Kurpisz, M. K. (2022). Evaluation of seminal plasma HSPA2 protein as a biomarker of human spermatogenesis status. Reproductive Biology, 22(1), 100597.

Zhang, W., Shi, B., Li, S., Liu, Z., Li, S., Dong, S., ... & Zhong, M. (2022). Sleeve gastrectomy improves lipid dysmetabolism by downregulating the USP20-HSPA2 axis in diet-induced obese mice. Frontiers in Endocrinology, 13, 1041027.

Dong, Y., Li, T., Ma, Z., Zhou, C., Wang, X., & Li, J. (2022). HSPA1A, HSPA2, and HSPA8 are potential molecular biomarkers for prognosis among HSP70 family in alzheimer’s disease. Disease Markers, 2022.

Panitch, R., Hu, J., Chung, J., Zhu, C., Meng, G., Xia, W., ... & Jun, G. R. (2021). Integrative brain transcriptome analysis links complement component 4 and HSPA2 to the APOE ε2 protective effect in Alzheimer disease. Molecular psychiatry, 26(10), 6054-6064.

Huerta-Retamal, N., Sáez-Espinosa, P., Robles-Gómez, L., Avilés, M., Romero, A., Aizpurua, J., & Gómez-Torres, M. J. (2021). Human sperm chaperone HSPA2 distribution during in vitro capacitation. Journal of reproductive immunology, 143, 103246.

Yang, Y. L., Zhang, Y., Li, D. D., Zhang, F. L., Liu, H. Y., Liao, X. H., ... & Shao, Z. M. (2020). RNF144A functions as a tumor suppressor in breast cancer through ubiquitin ligase activity-dependent regulation of stability and oncogenic functions of HSPA2. Cell Death & Differentiation, 27(3), 1105-1118.

Sojka, D. R., Gogler-Pigłowska, A., Vydra, N., Cortez, A. J., Filipczak, P. T., Krawczyk, Z., & Scieglinska, D. (2019). Functional redundancy of HSPA1, HSPA2 and other HSPA proteins in non-small cell lung carcinoma (NSCLC); an implication for NSCLC treatment. Scientific Reports, 9(1), 14394.

Cao, L., Yuan, X., Bao, F., Lv, W., He, Z., Tang, J., ... & Hu, J. (2019). Downregulation of HSPA2 inhibits proliferation via ERK1/2 pathway and endoplasmic reticular stress in lung adenocarcinoma. Annals of Translational Medicine, 7(20).

Seify, M., Zarabadipour, M., Ghaleno, L. R., Alizadeh, A., & Valojerdi, M. R. (2019). The anti-oxidant roles of Taurine and Hypotaurine on acrosome integrity, HBA and HSPA2 of the human sperm during vitrification and post warming in two different temperature. Cryobiology, 90, 89-95.

Petyuk, V. A., Chang, R., Ramirez-Restrepo, M., Beckmann, N. D., Henrion, M. Y., Piehowski, P. D., ... & Myers, A. J. (2018). The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease target. Brain, 141(9), 2721-2739.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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