HSPH1

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
Full Name
Heat Shock Protein Family H (Hsp110) Member 1
Function
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877).

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Biological Process
Chaperone cofactor-dependent protein refolding Source: Ensembl
Positive regulation of MHC class I biosynthetic process Source: BHF-UCL
Positive regulation of NK T cell activation Source: BHF-UCL
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm
PTM
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
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Anti-HSPH1 antibodies

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Mouse Anti-HSPH1 Recombinant Antibody (CAP905) (CBMAB-AP2732LY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CAP905
Application*: ICC, IHC, IP, WB
Datasheet SDS

Mouse Anti-HSPH1 Recombinant Antibody (3D10) (CBMAB-BR272LY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3D10
Application*: FC, IF, IHC-P, ICC, WB
Datasheet SDS

Mouse Anti-HSPH1 Recombinant Antibody (CBFYH-2485) (CBMAB-H3499-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2485
Application*: WB, IC, C, E
Datasheet SDS

Mouse Anti-HSPH1 Recombinant Antibody (CBFYH-2484) (CBMAB-H3498-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2484
Application*: E
Datasheet SDS

Mouse Anti-HSPH1 (AA 1-858) Recombinant Antibody (CBFYH-2483) (CBMAB-H3497-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBFYH-2483
Application*: E, WB
Datasheet SDS

Mouse Anti-HSPH1 (C-terminus) Recombinant Antibody (CBFYH-2479) (CBMAB-H3494-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBFYH-2479
Application*: IH, WB
Datasheet SDS

Mouse Anti-HSPH1 (AA 388-505) Recombinant Antibody (CBFYH-2478) (CBMAB-H3493-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rat
Clone: CBFYH-2478
Application*: WB
Datasheet SDS

Mouse Anti-HSPH1 (AA 388-505) Recombinant Antibody (CBFYH-2477) (CBMAB-H3492-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBFYH-2477
Application*: WB
Datasheet SDS

Mouse Anti-HSPH1 (C-terminus) Recombinant Antibody (CBFYH-2476) (CBMAB-H3491-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2476
Application*: P, WB
Datasheet SDS

Mouse Anti-HSPH1 (AA 388-505) Recombinant Antibody (CBFYH-2480) (CBMAB-H0661-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBFYH-2480
Application*: E, IC, WB
Datasheet SDS

Mouse Anti-HSPH1 (AA 1-858 ) Recombinant Antibody (J1G12) (CBMAB-H0194-FY)

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Target: HSPH1
Host: Mouse
Antibody Isotype: IgG2b, κ
Specificity: Human
Clone: J1G12
Application*: WB, E
Datasheet SDS
More Infomation
Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized) Submit A Review Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized) Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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