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Mouse Anti-HSPH1 Recombinant Antibody (3D10) (CBMAB-BR272LY)

The product is antibody recognizes HSPH1. The antibody 3D10 immunoassay techniques such as: FC, IF, IHC-P, ICC, WB.
See all HSPH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3D10
Antibody Isotype
IgG1
Application
FC: 1-3 μg/1x10 cells, IF: 1:1000 dilution, IHC-P: 0.5-1 μg/ml, ICC: 1:200 dilution, WB: 0.1-0.5 μg/ml

Basic Information

Immunogen
E. coli-derived human Hsp105 recombinant protein (Position: Y653-D858).
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Preservative
0.05 mg sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Heat Shock Protein Family H (Hsp110) Member 1
Introduction
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]
Entrez Gene ID
10808
UniProt ID
Q92598
Alternative Names
Heat shock protein 105 kDa; Antigen NY-CO-25; Heat shock 110 kDa protein; HSPH1; HSP105; HSP110; KIAA0201
Function
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877).

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Biological Process
Chaperone cofactor-dependent protein refolding Source: Ensembl
Positive regulation of MHC class I biosynthetic process Source: BHF-UCL
Positive regulation of NK T cell activation Source: BHF-UCL
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm
PTM
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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