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Mouse Anti-HSPH1 (AA 1-858 ) Recombinant Antibody (J1G12) (CBMAB-H0194-FY)

This product is mouse antibody that recognizes HSPH1. The antibody J1G12 can be used for immunoassay techniques such as: WB, ELISA.
See all HSPH1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
J1G12
Antibody Isotype
IgG2b, κ
Application
WB, ELISA

Basic Information

Immunogen
Recombinant human HSP105 alpha purified from E. coli
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1-858

Target

Full Name
Heat Shock Protein Family H (Hsp110) Member 1
Introduction
This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers.
Entrez Gene ID
10808
UniProt ID
Q92598
Alternative Names
Heat Shock Protein Family H (Hsp110) Member 1; Heat Shock 105kDa/110kDa Protein 1; Antigen NY-CO-25; HSP105; Heat Shock Protein 105 KDa; Heat Shock 110 KDa Protein
Function
Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877).

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).
Biological Process
Chaperone cofactor-dependent protein refolding Source: Ensembl
Positive regulation of MHC class I biosynthetic process Source: BHF-UCL
Positive regulation of NK T cell activation Source: BHF-UCL
Response to unfolded protein Source: ProtInc
Cellular Location
Cytoplasm
PTM
Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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