Mouse Anti-HSPH1 Recombinant Antibody (CAP905) (CBMAB-AP2732LY)

Name: Mouse Anti-HSPH1 Recombinant Antibody (CAP905)
SKU: CBMAB-AP2732LY
Rating: 5 (1 reviews)

See all HSPH1 antibodies

Compare Online Inquiry

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CAP905

Application

ICC, IHC, IP, WB

Specificity

Human

Antibody Isotype

IgG

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

More Infomation

Target

Full Name

Heat Shock Protein Family H (Hsp110) Member 1

Introduction

This gene encodes a member of the heat shock protein 70 family of proteins. The encoded protein functions as a nucleotide exchange factor for the molecular chaperone heat shock cognate 71 kDa protein (Hsc70). In addition, this protein plays a distinct but related role as a holdase that inhibits the aggregation of misfolded proteins, including the cystic fibrosis transmembrane conductance regulator (CFTR) protein. Elevated expression of this protein has been observed in numerous human cancers. [provided by RefSeq, Mar 2017]

Entrez Gene ID

10808

UniProt ID

Q92598

Alternative Names

Heat Shock Protein Family H (Hsp110) Member 1; Heat Shock 105kDa/110kDa Protein 1; Antigen NY-CO-25; HSP105; Heat Shock Protein 105 KDa; Heat Shock 110 KDa Protein;

Function

Acts as a nucleotide-exchange factor (NEF) for chaperone proteins HSPA1A and HSPA1B, promoting the release of ADP from HSPA1A/B thereby triggering client/substrate protein release (PubMed:24318877).

Prevents the aggregation of denatured proteins in cells under severe stress, on which the ATP levels decrease markedly. Inhibits HSPA8/HSC70 ATPase and chaperone activities (By similarity).

Biological Process

Chaperone cofactor-dependent protein refolding Source: Ensembl
Positive regulation of MHC class I biosynthetic process Source: BHF-UCL
Positive regulation of NK T cell activation Source: BHF-UCL
Response to unfolded protein Source: ProtInc

Cellular Location

Cytoplasm

PTM

Phosphorylation on Ser-509 may be important for regulation of the HSPA8/HSC70 chaperone activity.

Franco, J. C., Nogueira, M. L., Gandelini, G. M., Pinheiro, G. M., Gonçalves, C. C., Barbosa, L. R., ... & Ramos, C. H. (2023). Sorghum bicolor S b HSP110 has an elongated shape and is able of protecting against aggregation and replacing human HSPH1/HSP110 in refolding and disaggregation assays. Biopolymers, 114(2), e23532.

Liang, Y., Luo, J., Yang, N., Wang, S., Ye, M., & Pan, G. (2020). Activation of the IL-1β/KLF2/HSPH1 pathway promotes STAT3 phosphorylation in alveolar macrophages during LPS-induced acute lung injury. Bioscience Reports, 40(3), BSR20193572.

Li, Y., Zhang, N., Zhang, L., Song, Y., Liu, J., Yu, J., & Yang, M. (2020). Oncogene HSPH1 modulated by the rs2280059 genetic variant diminishes EGFR-TKIs efficiency in advanced lung adenocarcinoma. Carcinogenesis, 41(9), 1195-1202.

Ask a question We look forward to hearing from you.

0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Have you used Mouse Anti-HSPH1 Recombinant Antibody (CAP905)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon

$30 eGift Card
Submit a review

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-HSPH1 (AA 388-505) Recombinant Antibody (CBFYH-2478) (CAT#: CBMAB-H3493-FY)

Mouse Anti-HSPH1 Recombinant Antibody (CBFYH-2485) (CAT#: CBMAB-H3499-FY)

Mouse Anti-HSPH1 (C-terminus) Recombinant Antibody (CBFYH-2476) (CAT#: CBMAB-H3491-FY)

Mouse Anti-HSPH1 (AA 1-858 ) Recombinant Antibody (J1G12) (CAT#: CBMAB-H0194-FY)

Mouse Anti-HSPH1 (AA 1-858) Recombinant Antibody (CBFYH-2483) (CAT#: CBMAB-H3497-FY)

Mouse Anti-HSPH1 Recombinant Antibody (3D10) (CAT#: CBMAB-BR272LY)

Mouse Anti-HSPH1 (AA 388-505) Recombinant Antibody (CBFYH-2477) (CAT#: CBMAB-H3492-FY)

Mouse Anti-HSPH1 Recombinant Antibody (CBFYH-2484) (CAT#: CBMAB-H3498-FY)

Mouse Anti-HSPH1 (AA 388-505) Recombinant Antibody (CBFYH-2480) (CAT#: CBMAB-H0661-FY)

Mouse Anti-HSPH1 (C-terminus) Recombinant Antibody (CBFYH-2479) (CAT#: CBMAB-H3494-FY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Request bulk or custom quote Second antibody and isotype control

Contact us

Tel: (USA)
(UK)
Fax:

Global Locations

Email:

Online Inquiry