HTR1E

HTR1E (5-Hydroxytryptamine Receptor 1E) is a Protein Coding gene. Diseases associated with HTR1E include Spherocytosis, Type 3 and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1F.

Full Name

5-Hydroxytryptamine Receptor 1E

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-22
Helical: 23-47
Cytoplasmic: 48-59
Helical: 60-82
Extracellular: 83-96
Helical: 97-118
Cytoplasmic: 119-138
Helical: 139-159
Extracellular: 160-179
Helical: 180-202
Cytoplasmic: 203-291
Helical: 292-314
Extracellular: 315-324
Helical: 325-347
Cytoplasmic: 348-365