Rabbit Anti-HTR1E Recombinant Antibody (CBLQ5-012) (CBMAB-1965CQ)

Name: Rabbit Anti-HTR1E Recombinant Antibody (CBLQ5-012)
SKU: CBMAB-1965CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBLQ5-012

Application

WB, IHC-P, FC

Specificity

Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

5-Hydroxytryptamine Receptor 1E

Introduction

Serotonin (5-hydroxytryptamine; 5-HT) is a neurotransmitter thought to play a role in various cognitive and behavioral functions including feeding, sleep, pain, depression, and learning. Serotonin receptors have been divided into classes depending on their ligand binding and effector-coupling properties. G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Entrez Gene ID

3354

UniProt ID

P28566

Alternative Names

5-HT1E

Function

G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.

Biological Process

Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central

Cellular Location

Cell membrane

Topology

Extracellular: 1-22
Helical: 23-47
Cytoplasmic: 48-59
Helical: 60-82
Extracellular: 83-96
Helical: 97-118
Cytoplasmic: 119-138
Helical: 139-159
Extracellular: 160-179
Helical: 180-202
Cytoplasmic: 203-291
Helical: 292-314
Extracellular: 315-324
Helical: 325-347
Cytoplasmic: 348-365

Sharma, V. K., Campbell, K., XUYU, Y., Dale, R., & Loh, Y. P. (2023). Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival.

Qin, X., Li, J., Wang, S., Lv, J., Luan, F., Liu, Y., ... & Wang, L. (2021). Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Theranostics, 11(14), 6950.

Sun, C., Qiu, Y., Ren, Q., Zhang, X., Cao, B., Zou, Y., ... & Wang, Y. (2021). Molecular cloning and functional characterization of three 5-HT receptor genes (HTR1B, HTR1E, and HTR1F) in chickens. Genes, 12(6), 891.

Sharma, V. K., Xuyu, Y., Sanchez, D. S., Kim, S. K., Goddard III, W. A., & Loh, Y. P. (2020). Extracellular interaction between Neurotrophic factor‐α1 and HTR1E serotonin receptor promotes cell survival. The FASEB Journal, 34(S1), 1-1.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Mouse Anti-HTR1E Recombinant Antibody (2E9) (CAT#: CBMAB-A4151-LY)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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