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Rabbit Anti-HTR1E Recombinant Antibody (EG1587) (CBMAB-EN1900-LY)

The product is antibody recognizes HTR1E. The antibody EG1587 immunoassay techniques such as: WB: 1:500~1:1000 ELISA: 1:1000.
See all HTR1E antibodies

Summary

Host Animal
Rabbit
Specificity
Human
Clone
EG1587
Antibody Isotype
IgG
Application
WB: 1:500~1:1000 ELISA: 1:1000

Basic Information

Immunogen
The antibody was produced against synthesized peptide derived from internal of human 5-HT-1E.
Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
5-Hydroxytryptamine Receptor 1E
Introduction
HTR1E (5-Hydroxytryptamine Receptor 1E) is a Protein Coding gene. Diseases associated with HTR1E include Spherocytosis, Type 3 and Attention Deficit-Hyperactivity Disorder. Among its related pathways are Monoamine GPCRs and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G-protein coupled receptor activity and serotonin binding. An important paralog of this gene is HTR1F.
Entrez Gene ID
3354
UniProt ID
P28566
Alternative Names
5-Hydroxytryptamine Receptor 1E; 5-Hydroxytryptamine (Serotonin) Receptor 1E, G Protein-Coupled; Serotonin Receptor 1E; 5-HT-1E; 5-HT1E; S31; 5-Hydroxytryptamine (Serotonin) Receptor 1E;
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-22
Helical: 23-47
Cytoplasmic: 48-59
Helical: 60-82
Extracellular: 83-96
Helical: 97-118
Cytoplasmic: 119-138
Helical: 139-159
Extracellular: 160-179
Helical: 180-202
Cytoplasmic: 203-291
Helical: 292-314
Extracellular: 315-324
Helical: 325-347
Cytoplasmic: 348-365

Sharma, V. K., Campbell, K., XUYU, Y., Dale, R., & Loh, Y. P. (2023). Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival.

Sharma, V. K., Yang, X., Kim, S. K., Mafi, A., Saiz-Sanchez, D., Villanueva-Anguita, P., ... & Toulabi, L. (2023). Correction to: Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling. Cellular and Molecular Life Sciences, 80(3).

Sharma, V. K., Yang, X., Kim, S. K., Mafi, A., Saiz-Sanchez, D., Villanueva-Anguita, P., ... & Loh, Y. P. (2022). Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling. Cellular and Molecular Life Sciences, 79(1), 24.

Qin, X., Li, J., Wang, S., Lv, J., Luan, F., Liu, Y., ... & Wang, L. (2021). Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Theranostics, 11(14), 6950.

Sun, C., Qiu, Y., Ren, Q., Zhang, X., Cao, B., Zou, Y., ... & Wang, Y. (2021). Molecular cloning and functional characterization of three 5-HT receptor genes (HTR1B, HTR1E, and HTR1F) in chickens. Genes, 12(6), 891.

Sharma, V. K., Xuyu, Y., Sanchez, D. S., Kim, S. K., Goddard III, W. A., & Loh, Y. P. (2020). Extracellular interaction between Neurotrophic factor‐α1 and HTR1E serotonin receptor promotes cell survival. The FASEB Journal, 34(S1), 1-1.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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