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Mouse Anti-HTR1E Recombinant Antibody (2E9) (CBMAB-A4151-LY)

The product is antibody recognizes HTR1E. The antibody 2E9 immunoassay techniques such as: WB, ELISA.
See all HTR1E antibodies
Published Data
Fig. 1 Specificity of the anti-5-ht1E antibody assessed in recombinant cell lines.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
2E9
Antibody Isotype
IgG2a, κ
Application
WB, ELISA

Basic Information

Immunogen
HTR1E (NP_000856.1, 206 a.a. ~ 276 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
5-Hydroxytryptamine Receptor 1E
Entrez Gene ID
3354
UniProt ID
P28566
Alternative Names
5-HT1E
Function
G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.
Biological Process
Adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway Source: UniProtKB
Adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
Chemical synaptic transmission Source: GO_Central
G protein-coupled receptor signaling pathway Source: ProtInc
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
Cellular Location
Cell membrane
Topology
Extracellular: 1-22
Helical: 23-47
Cytoplasmic: 48-59
Helical: 60-82
Extracellular: 83-96
Helical: 97-118
Cytoplasmic: 119-138
Helical: 139-159
Extracellular: 160-179
Helical: 180-202
Cytoplasmic: 203-291
Helical: 292-314
Extracellular: 315-324
Helical: 325-347
Cytoplasmic: 348-365

Sharma, V. K., Campbell, K., XUYU, Y., Dale, R., & Loh, Y. P. (2023). Characterization of serotonin-5-HTR1E signaling pathways and its role in cell survival.

Sharma, V. K., Yang, X., Kim, S. K., Mafi, A., Saiz-Sanchez, D., Villanueva-Anguita, P., ... & Toulabi, L. (2023). Correction to: Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling. Cellular and Molecular Life Sciences, 80(3).

Sharma, V. K., Yang, X., Kim, S. K., Mafi, A., Saiz-Sanchez, D., Villanueva-Anguita, P., ... & Loh, Y. P. (2022). Novel interaction between neurotrophic factor-α1/carboxypeptidase E and serotonin receptor, 5-HTR1E, protects human neurons against oxidative/neuroexcitotoxic stress via β-arrestin/ERK signaling. Cellular and Molecular Life Sciences, 79(1), 24.

Qin, X., Li, J., Wang, S., Lv, J., Luan, F., Liu, Y., ... & Wang, L. (2021). Serotonin/HTR1E signaling blocks chronic stress-promoted progression of ovarian cancer. Theranostics, 11(14), 6950.

Sun, C., Qiu, Y., Ren, Q., Zhang, X., Cao, B., Zou, Y., ... & Wang, Y. (2021). Molecular cloning and functional characterization of three 5-HT receptor genes (HTR1B, HTR1E, and HTR1F) in chickens. Genes, 12(6), 891.

Sharma, V. K., Xuyu, Y., Sanchez, D. S., Kim, S. K., Goddard III, W. A., & Loh, Y. P. (2020). Extracellular interaction between Neurotrophic factor‐α1 and HTR1E serotonin receptor promotes cell survival. The FASEB Journal, 34(S1), 1-1.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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