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ICA1

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Full Name

Islet Cell Autoantigen 1

Function

May play a role in neurotransmitter secretion.

Biological Process

Neurotransmitter transport Source: UniProtKB-KW
Regulation of insulin secretion Source: InterPro
Regulation of transport Source: GO_Central

Cellular Location

Cytosol; Golgi apparatus membrane; Secretory vesicle membrane; Synaptic vesicle membrane. Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.

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Anti-ICA1 antibodies

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Mouse Anti-ICA1 Recombinant Antibody (A346) (CBMAB-AP4023LY)

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Target: ICA1

Host: Mouse

Antibody Isotype: IgG

Specificity: Human, Rat

Clone: A346

Application*: ICC, IHC, IP, WB

Mouse Anti-ICA1 Recombinant Antibody (6G11) (CBMAB-I1581-YY)

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Target: ICA1

Host: Mouse

Antibody Isotype: IgG2a, κ

Specificity: Human

Clone: 6G11

Application*: E, WB

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(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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