ICA1

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Islet Cell Autoantigen 1

May play a role in neurotransmitter secretion.

Neurotransmitter transport Source: UniProtKB-KW
Regulation of insulin secretion Source: InterPro
Regulation of transport Source: GO_Central

Cytosol; Golgi apparatus membrane; Secretory vesicle membrane; Synaptic vesicle membrane. Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.