Mouse Anti-ICA1 Recombinant Antibody (A346) (CBMAB-AP4023LY)

The product is antibody recognizes ICA1. The antibody A346 immunoassay techniques such as: ICC, IHC, IP, WB.
See all ICA1 antibodies

Datasheet

Summary

Host Animal

Mouse

Specificity

Human, Rat

Clone

A346

Antibody Isotype

IgG

Application

ICC, IHC, IP, WB

Basic Information

Immunogen

Met1~Gly258

Specificity

Human, Rat

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Purity

Affinity purity

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name

Islet Cell Autoantigen 1

Introduction

This gene encodes a protein with an arfaptin homology domain that is found both in the cytosol and as membrane-bound form on the Golgi complex and immature secretory granules. This protein is believed to be an autoantigen in insulin-dependent diabetes mellitus and primary Sjogren's syndrome. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]

Entrez Gene ID

Human	3382
Rat	81024

UniProt ID

Human	Q05084
Rat	Q63054

Alternative Names

Islet Cell Autoantigen 1

Function

May play a role in neurotransmitter secretion.

Biological Process

Neurotransmitter transport Source: UniProtKB-KW
Regulation of insulin secretion Source: InterPro
Regulation of transport Source: GO_Central

Cellular Location

Cytosol; Golgi apparatus membrane; Secretory vesicle membrane; Synaptic vesicle membrane. Predominantly cytosolic. Also exists as a membrane-bound form which has been found associated with synaptic vesicles and also with the Golgi complex and immature secretory granules.

References

Dashti, M., Nizam, R., Hebbar, P., Jacob, S., John, S. E., Channanath, A., ... & Al-Mulla, F. (2022). ICA1 is differentially methylated and expressed in familial type 1 diabetes.

Chen, L., Tao, F., Zhang, Y., Shu, C., Xiang, W., Yang, L., ... & Lyu, J. (2020). Islet‐cell autoantigen 69 accelerates liver regeneration by downregulating Tgfbr1 and attenuating Tgfβ signaling in mice. FEBS letters, 594(17), 2881-2893.

Han, K., Zhang, A., Mo, Y., Mao, T., Ji, B., Li, D., ... & Wang, J. (2019). Islet-cell autoantigen 69 mediates the antihyperalgesic effects of electroacupuncture on inflammatory pain by regulating spinal glutamate receptor subunit 2 phosphorylation through protein interacting with C-kinase 1 in mice. Pain, 160(3), 712.

Ariff, A., Melton, P. E., Brennecke, S. P., & Moses, E. K. (2019). Analysis of the epigenome in multiplex pre-eclampsia families identifies SORD, DGKI, and ICA1 as novel candidate risk genes. Frontiers in genetics, 10, 227.

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Protocols

Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Associated Products

Related Products

Mouse Anti-ICA1 Recombinant Antibody (6G11)

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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