IGFBP4
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]
Full Name
Insulin Like Growth Factor Binding Protein 4
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Biological Process
Inflammatory response Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Regulation of cell growth Source: Ensembl
Regulation of glucose metabolic process Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Type B pancreatic cell proliferation Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Regulation of cell growth Source: Ensembl
Regulation of glucose metabolic process Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Type B pancreatic cell proliferation Source: Ensembl
Cellular Location
Secreted
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Anti-IGFBP4 antibodies
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CompareTarget: IGFBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A438
Application*: ICC, IHC, IP, WB
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG
Specificity: Human, Rat
Clone: A437
Application*: ICC, IHC, IP, WB
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Rat
Clone: A436
Application*: ICC, IHC, IP, WB
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG2
Specificity: Human
Clone: CBYY-I1297
Application*: N, WB
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1043
Application*: E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: B1532M
Application*: E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0769
Application*: WB, N, EC
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0721
Application*: WB
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human, Mouse
Clone: CBYY-I0061
Application*: E, Sandwich E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human, Mouse
Clone: CBYY-I0060
Application*: E, Sandwich E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBYY-I0058
Application*: E, Sandwich E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human, Mouse
Clone: CBYY-I0057
Application*: E, Sandwich E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 1.A.17
Application*: WB, E, P
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYC-A980
Application*: E, WB
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: IBP3
Application*: E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: IBP185
Application*: E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: IBP163
Application*: E
Target: IGFBP4
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: IBP144
Application*: E
Target: IGFBP4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-254
Tag: His Tag
Target: IGFBP4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-258
Tag: His Tag
Target: IGFBP4
Expressed Host: HEK293 Cells
Sequence: Amino Acid: 1-258
Tag: His Tag
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(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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