Mouse Recombinant IGFBP4 protein, His Tag (V2LY-0526-LY8441)

Name: Mouse Recombinant IGFBP4 protein, His Tag
SKU: V2LY-0526-LY8441
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Expressed Host

HEK293 Cells

Protein Species

Mouse

Tag

His Tag

Protein Construction

This product is Mouse Recombinant IGFBP4 protein, His Tag consist of Amino Acid: 1-254 and predicts a molecular mass of 27.2 kDa.

Molecule Mass

27.2 kDa

Sequence

Amino Acid: 1-254

Species

Mouse

Formulations & Storage [For reference only, actual COA shall prevail!]

Purity

>95% as determined by SDS-PAGE

Endotoxin

Please contact us for more information.

Format

Lyophilized

Reconstitution

Allow the vial and reconstitution buffer to equilibrate to room temperature. Briefly centrifuge or tap down the vial to ensure that all lyophilized powder is collected at the bottom of the vial. For the reconstitution of this product, we recommend adding PBS or sterile water to achieve a final antibody concentration of 1 mg/mL. Allow the vial to reconstitute for 10-15 minutes at room temperature with gentle agitation. Avoid vigorous shaking that can cause foaming and antibody denaturation. Aliquot into volumes based on your experiment and store liquid protein at -20°C or -80°C for long time.

Buffer

Lyophilized from sterile PBS

Preservative

None

Storage

Samples are stable for up to twelve months from date of receipt at -20°C to -80°C. Store it under sterile conditions at -20°C to -80°C. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

More Infomation

Target

Full Name

Insulin Like Growth Factor Binding Protein 4

Function

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

Biological Process

Inflammatory response Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Regulation of cell growth Source: Ensembl
Regulation of glucose metabolic process Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Type B pancreatic cell proliferation Source: Ensembl

Cellular Location

Secreted

Adasheva, D. A., Lebedeva, O. S., Goliusova, D. V., Postnikov, A. B., Teriakova, M. V., Kopylova, I. V., ... & Serebryanaya, D. V. (2023). PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. International Journal of Molecular Sciences, 24(9), 8420.

Bhattarai, A., Singh Sunar, P., Shah, S., Chamlagain, R., Babu Pokhrel, N., Khanal, P., ... & Bhattarai, A. (2022). CT-IGFBP-4 as a Predictive Novel Biomarker of Ischemic Cardiovascular Events and Mortality: A Systematic Review. Journal of Interventional Cardiology, 2022.

Ruan, P., Wang, S., Yang, C., Huang, X., Sun, P., & Tan, A. (2022). m6A mRNA methylation regulates the ERK/NF-κB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer. Cell Biology and Toxicology, 1-16.

Nur, S. I., Ozturk, A., Kavas, M., Bulut, I., Alparslan, S., Aydogan, E. S., ... & Coskun, A. (2021). IGFBP-4: A promising biomarker for lung cancer. Journal of Medical Biochemistry, 40(3), 237.

Serebryanaya, D. V., Adasheva, D. A., Konev, A. A., Artemieva, M. M., Katrukha, I. A., Postnikov, A. B., ... & Katrukha, A. G. (2021). IGFBP-4 proteolysis by PAPP-A in a primary culture of rat neonatal cardiomyocytes under normal and hypertrophic conditions. Biochemistry (Moscow), 86, 1395-1406.

Konev, A. A., Kharitonov, A. V., Rozov, F. N., Altshuler, E. P., Serebryanaya, D. V., Lassus, J., ... & Postnikov, A. B. (2020). CT‐IGFBP‐4 as a novel prognostic biomarker in acute heart failure. ESC heart failure, 7(2), 434-444.

Alessio, N., Squillaro, T., Di Bernardo, G., Galano, G., De Rosa, R., Melone, M. A., ... & Galderisi, U. (2020). Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence. Elife, 9, e54523.

DiPrisco, B., Kumar, A., Kalra, B., Savjani, G. V., Michael, Z., Farr, O., ... & Mantzoros, C. (2019). Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and-5), and IGF-I and IGF-II: levels in umbilical cord blood and associations with birth weight and length. Metabolism, 100, 153959.

Lee, Y. Y., Mok, M. T., Kang, W., Yang, W., Tang, W., Wu, F., ... & Cheng, A. S. (2018). Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. Nucleic acids research, 46(17), 8832-8847.

Hjortebjerg, R. (2018). IGFBP-4 and PAPP-A in normal physiology and disease. Growth Hormone & IGF Research, 41, 7-22.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Cynomolgus Recombinant IGFBP4 protein, His Tag (CAT#: V2LY-0526-LY1543)

Human Recombinant IGFBP4 protein, His Tag (CAT#: V2LY-0526-LY4670)

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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