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Mouse Anti-IGFBP4 Recombinant Antibody (CBYC-A980) (CBMAB-A4472-YC)

Provided herein is a Mouse monoclonal antibody against Human Insulin Like Growth Factor Binding Protein 4. The antibody can be used for immunoassay techniques, such as ELISA, WB.
See all IGFBP4 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYC-A980
Antibody Isotype
IgG1
Application
ELISA, WB

Basic Information

Immunogen
Recombinant human IGFBP4 protein
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Insulin Like Growth Factor Binding Protein 4
Introduction
IGFBP4 belongs to the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma i
Entrez Gene ID
UniProt ID
Alternative Names
BP-4; HT29-IGFBP; IBP4; IGFBP-4
Function
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
Biological Process
Inflammatory response Source: Ensembl
Negative regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
Positive regulation of insulin-like growth factor receptor signaling pathway Source: Ensembl
Positive regulation of MAPK cascade Source: Ensembl
Regulation of cell growth Source: Ensembl
Regulation of glucose metabolic process Source: Ensembl
Regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
Signal transduction Source: ProtInc
Type B pancreatic cell proliferation Source: Ensembl
Cellular Location
Secreted

Adasheva, D. A., Lebedeva, O. S., Goliusova, D. V., Postnikov, A. B., Teriakova, M. V., Kopylova, I. V., ... & Serebryanaya, D. V. (2023). PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. International Journal of Molecular Sciences, 24(9), 8420.

Bhattarai, A., Singh Sunar, P., Shah, S., Chamlagain, R., Babu Pokhrel, N., Khanal, P., ... & Bhattarai, A. (2022). CT-IGFBP-4 as a Predictive Novel Biomarker of Ischemic Cardiovascular Events and Mortality: A Systematic Review. Journal of Interventional Cardiology, 2022.

Ruan, P., Wang, S., Yang, C., Huang, X., Sun, P., & Tan, A. (2022). m6A mRNA methylation regulates the ERK/NF-κB/AKT signaling pathway through the PAPPA/IGFBP4 axis to promote proliferation and tumor formation in endometrial cancer. Cell Biology and Toxicology, 1-16.

Nur, S. I., Ozturk, A., Kavas, M., Bulut, I., Alparslan, S., Aydogan, E. S., ... & Coskun, A. (2021). IGFBP-4: A promising biomarker for lung cancer. Journal of Medical Biochemistry, 40(3), 237.

Serebryanaya, D. V., Adasheva, D. A., Konev, A. A., Artemieva, M. M., Katrukha, I. A., Postnikov, A. B., ... & Katrukha, A. G. (2021). IGFBP-4 proteolysis by PAPP-A in a primary culture of rat neonatal cardiomyocytes under normal and hypertrophic conditions. Biochemistry (Moscow), 86, 1395-1406.

Konev, A. A., Kharitonov, A. V., Rozov, F. N., Altshuler, E. P., Serebryanaya, D. V., Lassus, J., ... & Postnikov, A. B. (2020). CT‐IGFBP‐4 as a novel prognostic biomarker in acute heart failure. ESC heart failure, 7(2), 434-444.

Alessio, N., Squillaro, T., Di Bernardo, G., Galano, G., De Rosa, R., Melone, M. A., ... & Galderisi, U. (2020). Increase of circulating IGFBP-4 following genotoxic stress and its implication for senescence. Elife, 9, e54523.

DiPrisco, B., Kumar, A., Kalra, B., Savjani, G. V., Michael, Z., Farr, O., ... & Mantzoros, C. (2019). Placental proteases PAPP-A and PAPP-A2, the binding proteins they cleave (IGFBP-4 and-5), and IGF-I and IGF-II: levels in umbilical cord blood and associations with birth weight and length. Metabolism, 100, 153959.

Lee, Y. Y., Mok, M. T., Kang, W., Yang, W., Tang, W., Wu, F., ... & Cheng, A. S. (2018). Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis. Nucleic acids research, 46(17), 8832-8847.

Hjortebjerg, R. (2018). IGFBP-4 and PAPP-A in normal physiology and disease. Growth Hormone & IGF Research, 41, 7-22.

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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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