IL23R

The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner. [provided by RefSeq]

Full Name

interleukin 23 receptor

Function

Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-negative bacterium1 PublicationIC:BHF-UCL
Inflammatory responseIEA:UniProtKB-KW
Interleukin-23-mediated signaling pathwayIEA:GOC
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of activated T cell proliferation1 PublicationIC:BHF-UCL
Positive regulation of activation of Janus kinase activity1 PublicationIC:BHF-UCL
Positive regulation of defense response to virus by hostManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of granulocyte macrophage colony-stimulating factor production1 PublicationIC:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-17 production1 PublicationIC:BHF-UCL
Positive regulation of memory T cell differentiationISS:BHF-UCL
Positive regulation of natural killer cell proliferation1 PublicationIC:BHF-UCL
Positive regulation of NK T cell activation1 PublicationIC:BHF-UCL
Positive regulation of osteoclast differentiation1 PublicationIC:BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STATIDA:ComplexPortal
Positive regulation of T cell mediated cytotoxicityISS:BHF-UCL
Positive regulation of T cell proliferation1 PublicationIDA:ComplexPortal
Positive regulation of T-helper 1 type immune responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T-helper 17 cell lineage commitmentISS:BHF-UCL
Positive regulation of T-helper 17 type immune responseISS:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein2 PublicationsIC:BHF-UCL
Regulation of tyrosine phosphorylation of STAT protein1 PublicationIC:BHF-UCL
Response to interferon-gammaManual Assertion Based On ExperimentIDA:BHF-UCL
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:BHF-UCL

Cellular Location

Cell membrane

Involvement in disease

Inflammatory bowel disease 17 (IBD17):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

Topology

Extracellular: 24-355
Helical: 356-376
Cytoplasmic: 377-629

PTM

Phosphorylated in response to IL23.