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Mouse Anti-IL23R Recombinant Antibody (9H143) (CBMAB-I1841-YY)

This product is Mouse antibody that recognizes IL23R. The antibody 9H143 can be used for immunoassay techniques such as: FC
See all IL23R antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
9H143
Antibody Isotype
IgG2b
Application
FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
0.5% BSA
Preservative
0.1% sodium azide
Concentration
0.05 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
interleukin 23 receptor
Introduction
The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.
Entrez Gene ID
149233
UniProt ID
Q5VWK5
Alternative Names
Interleukin 23 Receptor
Function
Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Defense response to Gram-negative bacterium1 PublicationIC:BHF-UCL
Inflammatory responseIEA:UniProtKB-KW
Interleukin-23-mediated signaling pathwayIEA:GOC
Negative regulation of interleukin-10 productionManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of activated T cell proliferation1 PublicationIC:BHF-UCL
Positive regulation of activation of Janus kinase activity1 PublicationIC:BHF-UCL
Positive regulation of defense response to virus by hostManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of granulocyte macrophage colony-stimulating factor production1 PublicationIC:BHF-UCL
Positive regulation of interferon-gamma productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-12 productionManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of interleukin-17 production1 PublicationIC:BHF-UCL
Positive regulation of memory T cell differentiationISS:BHF-UCL
Positive regulation of natural killer cell proliferation1 PublicationIC:BHF-UCL
Positive regulation of NK T cell activation1 PublicationIC:BHF-UCL
Positive regulation of osteoclast differentiation1 PublicationIC:BHF-UCL
Positive regulation of receptor signaling pathway via JAK-STATIDA:ComplexPortal
Positive regulation of T cell mediated cytotoxicityISS:BHF-UCL
Positive regulation of T cell proliferation1 PublicationIDA:ComplexPortal
Positive regulation of T-helper 1 type immune responseManual Assertion Based On ExperimentIDA:BHF-UCL
Positive regulation of T-helper 17 cell lineage commitmentISS:BHF-UCL
Positive regulation of T-helper 17 type immune responseISS:BHF-UCL
Positive regulation of tyrosine phosphorylation of STAT protein2 PublicationsIC:BHF-UCL
Regulation of tyrosine phosphorylation of STAT protein1 PublicationIC:BHF-UCL
Response to interferon-gammaManual Assertion Based On ExperimentIDA:BHF-UCL
Response to lipopolysaccharideManual Assertion Based On ExperimentIDA:BHF-UCL
Cellular Location
Cell membrane
Involvement in disease
Inflammatory bowel disease 17 (IBD17):
A chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.
Topology
Extracellular: 24-355
Helical: 356-376
Cytoplasmic: 377-629
PTM
Phosphorylated in response to IL23.

Staels, F., Lorenzetti, F., De Keukeleere, K., Willemsen, M., Gerbaux, M., Neumann, J., ... & Schrijvers, R. (2022). A novel homozygous stop mutation in IL23R causes mendelian susceptibility to mycobacterial disease. Journal of Clinical Immunology, 42(8), 1638-1652.

Soysal, E., Ulutaş, F., Tepeli, E., Kaymaz, S., & Çobankara, V. (2022). IL-23R gene polymorphisms in rheumatoid arthritis. Rheumatology International, 42(3), 555-562.

Zhu, Y., Jiang, H., Chen, Z., Lu, B., Li, J., & Shen, X. (2020). Genetic association between IL23R rs11209026 and rs10889677 polymorphisms and risk of Crohn’s disease and ulcerative colitis: Evidence from 41 studies. Inflammation Research, 69, 87-103.

Sun, R., Hedl, M., & Abraham, C. (2020). IL23 induces IL23R recycling and amplifies innate receptor-induced signalling and cytokines in human macrophages, and the IBD-protective IL23R R381Q variant modulates these outcomes. Gut, 69(2), 264-273.

Sun, R., & Abraham, C. (2020). IL23 promotes antimicrobial pathways in human macrophages, which are reduced with the IBD-protective IL23R R381Q variant. Cellular and molecular gastroenterology and hepatology, 10(4), 673-697.

Mohammadi, F. S., Aslani, S., Mostafaei, S., Jamshidi, A., Riahi, P., & Mahmoudi, M. (2019). Are genetic variations in IL‐21–IL‐23R–IL‐17A cytokine axis involved in a pathogenic pathway of rheumatoid arthritis? Bayesian hierarchical meta‐analysis. Journal of cellular physiology, 234(10), 17159-17171.

Mosallaei, M., Simonian, M., Esmaeilzadeh, E., Bagheri, H., Miraghajani, M., Salehi, A. R., ... & Salehi, R. (2019). Single nucleotide polymorphism rs10889677 in miRNAs Let-7e and Let-7f binding site of IL23R gene is a strong colorectal cancer determinant: Report and meta-analysis. Cancer genetics, 239, 46-53.

Poomarimuthu, M., Elango, S., Solomon, P. R., Soundrapandian, S., & Mariakuttikan, J. (2018). Association of IL17 and IL23R gene polymorphisms with rheumatic heart disease in South Indian population. Immunological Investigations, 47(7), 754-764.

Kasamatsu, T., Kimoto, M., Takahashi, N., Minato, Y., Gotoh, N., Takizawa, M., ... & Murakami, H. (2018). IL17A and IL23R gene polymorphisms affect the clinical features and prognosis of patients with multiple myeloma. Hematological Oncology, 36(1), 196-201.

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For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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