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Immune Checkpoint

Immune checkpoint is a kind of signal for regulating the antigen recognition of T cell receptor (TCR) in the process of immune responce. Immune checkpoint contains two kinds of signals: (1) Co-stimulatory immune checkpoint: stimulating immune progress, such as CD28, ICOS, and CD137; (2) Co-inhibitory immune checkpoint: inhibiting immune progress, such as PD1, CTLA-4, and VISTA. When immune system is attacking pathogens, these immune checkpoint molecules can protect the normal tissues from damage. The cancer cells cleverly escape from immune attack by dysregulating immune checkpoint related proteins. Immune checkpoint therapy relys on functioning immune system with agonists of co-stimulatory signals or antagonists of inhibitory signals.

Full Name

Immune checkpoint molecule

Anti-Immune Checkpoint antibodies

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Mouse Immune Checkpoint Antibody Array (Membrane, 11 Targets) (Y0215) (AbAr-0215-YC)

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Target Array: Immune Checkpoint Array

Species Reactivity: Mouse

Solid Support: Membrane

Assay Type: Semi-Quantitative

Human Immune Checkpoint Antibody Array (Membrane, 12 Targets) (Y0214) (AbAr-0214-YC)

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Target Array: Immune Checkpoint Array

Species Reactivity: Human

Solid Support: Membrane

Assay Type: Semi-Quantitative

Human Immune Checkpoint Antibody Array (Glass Slide, 10 Targets) (Y0543) (AbAr-0543-YC)

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Target Array: Immune Checkpoint Array

Species Reactivity: Human

Solid Support: Glass Slide

Assay Type: Semi-Quantitative

Rat Immune Checkpoint Antibody Array (Membrane, 9 Targets) (Y0542) (AbAr-0542-YC)

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Target Array: Immune Checkpoint Array

Species Reactivity: Rat

Solid Support: Membrane

Assay Type: Semi-Quantitative

Human Immune Checkpoint Antibody Array (Membrane, 11 Targets) (Y0213) (AbAr-0213-YC)

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Target Array: Immune Checkpoint Array

Species Reactivity: Human

Solid Support: Membrane

Assay Type: Semi-Quantitative

Human Immune Checkpoint Antibody Array (Membrane, 23 Targets) (Y0212) (AbAr-0212-YC)

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Target Array: Immune Checkpoint Array

Species Reactivity: Human

Solid Support: Membrane

Assay Type: Semi-Quantitative

Human Immune Checkpoint Antibody Array (Glass Slide, 10 Targets) (Y0181) (AbAr-0181-YC)

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Target Array: Immune Checkpoint Molecule Array

Species Reactivity: Human

Solid Support: Glass Slide

Assay Type: Quantitative

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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Fig.3 Signaling pathways in cancers. (Creative Biolabs Authorized)

Fig.4 Protocols troubleshootings & guides. (Creative Biolabs Authorized)

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For Research Use Only. Not For Clinical Use.

(P): Predicted

* Abbreviations

AActivation
AGAgonist
APApoptosis
BBlocking
BABioassay
BIBioimaging
CImmunohistochemistry-Frozen Sections
CIChromatin Immunoprecipitation
CTCytotoxicity
CSCostimulation
DDepletion
DBDot Blot

EELISA
ECELISA(Cap)
EDELISA(Det)
ESELISpot
EMElectron Microscopy
FFlow Cytometry
FNFunction Assay
GSGel Supershift
IInhibition
IAEnzyme Immunoassay
ICImmunocytochemistry
IDImmunodiffusion
IEImmunoelectrophoresis

IFImmunofluorescence
IGImmunochromatography
IHImmunohistochemistry
IMImmunomicroscopy
IOImmunoassay
IPImmunoprecipitation
ISIntracellular Staining for Flow Cytometry
LALuminex Assay
LFLateral Flow Immunoassay
MMicroarray
MCMass Cytometry/CyTOF
MDMeDIP

MSElectrophoretic Mobility Shift Assay
NNeutralization
PImmunohistologyp-Paraffin Sections
PAPeptide Array
PEPeptide ELISA
PLProximity Ligation Assay
RRadioimmunoassay
SStimulation
SESandwich ELISA
SHIn situ hybridization
TCTissue Culture
WBWestern Blot

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