ING5

This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants.

Full Name

Inhibitor Of Growth Family Member 5

Function

Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767).
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653).
Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653).
Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715).

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Biological Process DNA replicationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K14 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K12 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Histone H4-K5 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Histone H4-K8 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Histone modificationManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of growthManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIGI:MGI
Positive regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cell growthManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Nucleus; Chromosome. Localizes to transcription start sites.