Mouse Anti-ING5 Recombinant Antibody (CBYY-I1102) (CBMAB-I2270-YY)

Name: Mouse Anti-ING5 Recombinant Antibody (CBYY-I1102)
SKU: CBMAB-I2270-YY
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

CBYY-I1102

Application

ELISA

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

5% trehalose

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Inhibitor Of Growth Family Member 5

Introduction

This gene encodes a tumor suppressor protein that inhibits cell growth and induces apoptosis. This protein contains a PHD-type zinc finger. It interacts with tumor suppressor p53 and p300, a component of the histone acetyl transferase complex, suggesting a role in transcriptional regulation. Alternative splicing and the use of multiple promoters and 3' terminal exons results in multiple transcript variants.

Entrez Gene ID

84289

UniProt ID

Q8WYH8

Alternative Names

Inhibitor Of Growth Family Member 5

Function

Component of the HBO1 complex, which specifically mediates acetylation of histone H3 at 'Lys-14' (H3K14ac) and, to a lower extent, acetylation of histone H4 (PubMed:24065767).
Component of the MOZ/MORF complex which has a histone H3 acetyltransferase activity (PubMed:16387653).
Through chromatin acetylation it may regulate DNA replication and may function as a transcriptional coactivator (PubMed:12750254, PubMed:16387653).
Inhibits cell growth, induces a delay in S-phase progression and enhances Fas-induced apoptosis in an INCA1-dependent manner (PubMed:21750715).

Biological Process

Chromatin organizationIEA:UniProtKB-KW
Biological Process DNA replicationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H3-K14 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4 acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Histone H4-K12 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Histone H4-K5 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Histone H4-K8 acetylationManual Assertion Based On ExperimentIDA:ComplexPortal
Histone modificationManual Assertion Based On ExperimentIDA:ComplexPortal
Negative regulation of cell population proliferationManual Assertion Based On ExperimentIDA:UniProtKB
Negative regulation of growthManual Assertion Based On ExperimentIDA:UniProtKB
Positive regulation of apoptotic processManual Assertion Based On ExperimentIGI:MGI
Positive regulation of apoptotic signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
Positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Protein acetylationManual Assertion Based On ExperimentIDA:UniProtKB
Regulation of cell cycleManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of cell growthManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA biosynthetic processManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of DNA replicationManual Assertion Based On ExperimentIDA:ComplexPortal
Regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:ComplexPortal

Cellular Location

Nucleus; Chromosome. Localizes to transcription start sites.

Taheri, M., Hussen, B. M., Najafi, S., Abak, A., Ghafouri-Fard, S., Samsami, M., & Baniahmad, A. (2022). Molecular mechanisms of inhibitor of growth (ING) family members in health and malignancy. Cancer Cell International, 22(1), 272.

Ghafouri-Fard, S., Taheri, M., & Baniahmad, A. (2022). Inhibitor of growth factors regulate cellular senescence. Cancers, 14(13), 3107.

Xu, J. H., Zhao, J. X., Jiang, M. Y., Yang, L. P., Sun, M. L., & Wang, H. W. (2020). MiR-193 promotes cell proliferation and invasion by ING5/PI3K/AKT pathway of triple-negative breast cancer. European Review for Medical & Pharmacological Sciences, 24(6).

Xin, H., Wang, C., Chi, Y., & Liu, Z. (2020). MicroRNA-196b-5p promotes malignant progression of colorectal cancer by targeting ING5. Cancer Cell International, 20, 1-17.

Zhang, H., Zhou, J., Zhang, M., Yi, Y., & He, B. (2019). Upregulation of miR-376c-3p alleviates oxygen–glucose deprivation-induced cell injury by targeting ING5. Cellular & Molecular Biology Letters, 24(1), 1-12.

Gao, W., & Han, J. (2018). Overexpression of ING5 inhibits HGF-induced proliferation, invasion and EMT in thyroid cancer cells via regulation of the c-Met/PI3K/Akt signaling pathway. Biomedicine & Pharmacotherapy, 98, 265-270.

Zhang, X., Xu, Z. H., Xie, H., Sun, Y. W., Liu, J., & Zhao, Y. B. (2018). ING5 is a potential target for osteosarcoma therapy. Technology in Cancer Research & Treatment, 17, 1533033818762680.

Ye, P., Ke, X., Zang, X., Sun, H., Dong, Z., Lin, J., ... & Gao, L. (2018). Up-regulated MiR-27-3p promotes the G1-S phase transition by targeting inhibitor of growth family member 5 in osteosarcoma. Biomedicine & Pharmacotherapy, 101, 219-227.

Zhang, G. J., Zhao, J., Jiang, M. L., & Zhang, L. C. (2018). ING5 inhibits cell proliferation and invasion in esophageal squamous cell carcinoma through regulation of the Akt/NF-κB/MMP-9 signaling pathway. Biochemical and biophysical research communications, 496(2), 387-393.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

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