IRAK2
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 1 Receptor Associated Kinase 2
Function
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-1-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Lipopolysaccharide-mediated signaling pathwayIEA:Ensembl
MyD88-dependent toll-like receptor signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Response to interleukin-1Manual Assertion Based On ExperimentIMP:BHF-UCL
I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-1-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Lipopolysaccharide-mediated signaling pathwayIEA:Ensembl
MyD88-dependent toll-like receptor signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Response to interleukin-1Manual Assertion Based On ExperimentIMP:BHF-UCL
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Anti-IRAK2 antibodies
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CompareTarget: IRAK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1674
Application*: WB: 1:500~1:3000 ELISA: 1:40000
Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 4B6
Application*: WB, E
Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 3H1
Application*: WB, E
Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A6
Application*: WB, E
Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2067
Application*: WB, IH
Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1899
Application*: WB
Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6C7]
Application*: WB, IP, E, P
Target: IRAK2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYY-I0677
Application*: WB
Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C1
Application*: P, WB
Target: IRAK2
Expressed Host: Baculovirus-Insect Cells
Sequence: Amino Acid: Full Length
Tag: GST Tag
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For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
- AActivation
- AGAgonist
- APApoptosis
- BBlocking
- BABioassay
- BIBioimaging
- CImmunohistochemistry-Frozen Sections
- CIChromatin Immunoprecipitation
- CTCytotoxicity
- CSCostimulation
- DDepletion
- DBDot Blot
- EELISA
- ECELISA(Cap)
- EDELISA(Det)
- ESELISpot
- EMElectron Microscopy
- FFlow Cytometry
- FNFunction Assay
- GSGel Supershift
- IInhibition
- IAEnzyme Immunoassay
- ICImmunocytochemistry
- IDImmunodiffusion
- IEImmunoelectrophoresis
- IFImmunofluorescence
- IGImmunochromatography
- IHImmunohistochemistry
- IMImmunomicroscopy
- IOImmunoassay
- IPImmunoprecipitation
- ISIntracellular Staining for Flow Cytometry
- LALuminex Assay
- LFLateral Flow Immunoassay
- MMicroarray
- MCMass Cytometry/CyTOF
- MDMeDIP
- MSElectrophoretic Mobility Shift Assay
- NNeutralization
- PImmunohistologyp-Paraffin Sections
- PAPeptide Array
- PEPeptide ELISA
- PLProximity Ligation Assay
- RRadioimmunoassay
- SStimulation
- SESandwich ELISA
- SHIn situ hybridization
- TCTissue Culture
- WBWestern Blot
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