IRAK2

IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB. [provided by RefSeq, Jul 2008]
Full Name
Interleukin 1 Receptor Associated Kinase 2
Function
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-1-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Lipopolysaccharide-mediated signaling pathwayIEA:Ensembl
MyD88-dependent toll-like receptor signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Response to interleukin-1Manual Assertion Based On ExperimentIMP:BHF-UCL
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Anti-IRAK2 antibodies

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Rabbit Anti-IRAK2 Recombinant Antibody (EG1674) (CBMAB-EN2002-LY)

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Target: IRAK2
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human
Clone: EG1674
Application*: WB: 1:500~1:3000 ELISA: 1:40000
Datasheet SDS

Mouse Anti-IRAK2 Recombinant Antibody (4B6) (CBMAB-A4514-LY)

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Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse
Clone: 4B6
Application*: WB, E
Datasheet SDS

Mouse Anti-IRAK2 Recombinant Antibody (3H1) (CBMAB-A4513-LY)

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Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human, Mouse, Rat
Clone: 3H1
Application*: WB, E
Datasheet SDS

Mouse Anti-IRAK2 Recombinant Antibody (1A6) (CBMAB-A4512-LY)

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Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 1A6
Application*: WB, E
Datasheet SDS

Mouse Anti-IRAK2 Recombinant Antibody (CBYY-I2067) (CBMAB-I3237-YY)

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Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2067
Application*: WB, IH
Datasheet SDS

Mouse Anti-IRAK2 Recombinant Antibody (CBYY-I1899) (CBMAB-I3069-YY)

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Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1899
Application*: WB
Datasheet SDS

Mouse Anti-IRAK2 (AA 1-157) Recombinant Antibody (6C7]) (CBMAB-I1556-YY)

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Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 6C7]
Application*: WB, IP, E, P
Datasheet SDS

Mouse Anti-IRAK2 Recombinant Antibody (CBYY-I0677) (CBMAB-I1496-YY)

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Target: IRAK2
Host: Mouse
Antibody Isotype: IgG3
Specificity: Human
Clone: CBYY-I0677
Application*: WB
Datasheet SDS

Mouse Anti-IRAK2 Recombinant Antibody (4C1) (CBMAB-I1312-YY)

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Target: IRAK2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 4C1
Application*: P, WB
Datasheet SDS
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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