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Mouse Anti-IRAK2 Recombinant Antibody (CBYY-I2067) (CBMAB-I3237-YY)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I2067
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Human recombinant protein fragment corresponding to amino acids 362-625 of human IRAK2 (NP_001561)
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, PH 7.3, 1% BSA, 50% glycerol
Preservative
0.02% sodium azide
Concentration
1 mg/ml
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Interleukin 1 Receptor Associated Kinase 2
Introduction
IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.
Entrez Gene ID
3656
UniProt ID
O43187
Alternative Names
Interleukin 1 Receptor Associated Kinase 2
Function
Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.
Biological Process
Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-1-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Lipopolysaccharide-mediated signaling pathwayIEA:Ensembl
MyD88-dependent toll-like receptor signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Response to interleukin-1Manual Assertion Based On ExperimentIMP:BHF-UCL
More Infomation

Ferraro, F., Steinle, A., Narasimhan, H., Bleilevens, A., Stolzenberg, P. M., Braunschweig, T., ... & Maurer, J. (2023). IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models. International Journal of Molecular Sciences, 24(3), 2520.

Yang, J., Liu, D. J., Zheng, J. H., He, R. Z., Xu, D. P., Yang, M. W., ... & Liu, W. (2022). IRAK2-NF-κB signaling promotes glycolysis-dependent tumor growth in pancreatic cancer. Cellular Oncology, 45(3), 367-379.

Shao, S., Tsoi, L. C., Swindell, W. R., Chen, J., Uppala, R., Billi, A. C., ... & Gudjonsson, J. E. (2021). IRAK2 has a critical role in promoting feed-forward amplification of epidermal inflammatory responses. Journal of Investigative Dermatology, 141(10), 2436-2448.

Yu, C. C., Chan, M. W., Lin, H. Y., Chiou, W. Y., Lin, R. I., Chen, C. A., ... & Hung, S. K. (2021). IRAK2, an IL1R/TLR immune mediator, enhances radiosensitivity via modulating caspase 8/3-mediated apoptosis in oral squamous cell carcinoma. Frontiers in Oncology, 11, 647175.

Xiao, T., Sun, C., Xiao, Y., & Li, Y. (2020). lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p. Biology open, 9(6), bio049353.

Chen, Z., Zhou, J., Wang, X., Zhang, Y., Lu, X., Fan, Y., ... & Yang, Z. (2019). Screening candidate microR-15a-IRAK2 regulatory pairs for predicting the response to Staphylococcus aureus-induced mastitis in dairy cows. Journal of Dairy Research, 86(4), 425-431.

Guo, S., Chen, Y., Liu, J., Yang, J., Yang, C., Zhang, T., ... & Deng, G. (2019). miR‐497a‐5p attenuates lipopolysaccharide‐induced inflammatory injury by targeting IRAK2. Journal of cellular physiology, 234(12), 22874-22883.

Liu, J., Chen, Y., Huang, Q., Liu, W., Ji, X., Hu, F., ... & Dong, G. (2018). IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress. Cellular Signalling, 48, 69-80.

Xu, Y., Liu, H., Liu, S., Wang, Y., Xie, J., Stinchcombe, T. E., ... & Wei, Q. (2018). Genetic variant of IRAK2 in the toll‐like receptor signaling pathway and survival of non‐small cell lung cancer. International journal of cancer, 143(10), 2400-2408.

Liu, H., Yang, X., Zhang, Z. K., Zou, W. C., & Wang, H. N. (2018). miR-146a-5p promotes replication of infectious bronchitis virus by targeting IRAK2 and TNFRSF18. Microbial pathogenesis, 120, 32-36.

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For research use only. Not intended for any clinical use.

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