Human IRAK2 ELISA Kit (V2LY-0626-LY2589)

Name: Human IRAK2 ELISA Kit
SKU: V2LY-0626-LY2589
Rating: 5 (1 reviews)

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Tested Data

Datasheet

SDS

Request for COA

Datasheet Target References Q & As Review & reward Protocols Associated Products

Basic Information

Sensitivity

0.004 ng/mL

Detection Range

0.007-1.5 ng/mL

Sample Type

Serum, Plasma, cell culture supernates

Specificity

Human

Assay Type

Sandwich

Reactivity

Human

Assay Time

1.5 h

Molecule Mass

69.4 kDa

Components

Pre-coated ELISA Plate: 12 wells * 8 detachable strips
Standard solution: 0.5ml x1
Standard diluent: 3ml x1
Streptavidin-HRP: 6ml x1
Stop solution: 6ml x1
Substrate solution A: 6ml x1
Substrate solution B: 6ml x1
Wash buffer concentrate (25x): 20ml x1
Biotinylated antibody: 1ml x1

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at 2-8°C

More Infomation

Target

Full Name

Interleukin 1 Receptor Associated Kinase 2

Function

Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.

Biological Process

Cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIBA:GO_Central
I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentTAS:ProtInc
Inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Interleukin-1-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Intracellular signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Lipopolysaccharide-mediated signaling pathwayIEA:Ensembl
MyD88-dependent toll-like receptor signaling pathwayManual Assertion Based On ExperimentTAS:BHF-UCL
Negative regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:BHF-UCL
Protein phosphorylationManual Assertion Based On ExperimentTAS:ProtInc
Regulation of cytokine-mediated signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Response to interleukin-1Manual Assertion Based On ExperimentIMP:BHF-UCL

Ferraro, F., Steinle, A., Narasimhan, H., Bleilevens, A., Stolzenberg, P. M., Braunschweig, T., ... & Maurer, J. (2023). IRAK2 Downregulation in Triple-Negative Breast Cancer Cells Decreases Cellular Growth In Vitro and Delays Tumour Progression in Murine Models. International Journal of Molecular Sciences, 24(3), 2520.

Yang, J., Liu, D. J., Zheng, J. H., He, R. Z., Xu, D. P., Yang, M. W., ... & Liu, W. (2022). IRAK2-NF-κB signaling promotes glycolysis-dependent tumor growth in pancreatic cancer. Cellular Oncology, 45(3), 367-379.

Shao, S., Tsoi, L. C., Swindell, W. R., Chen, J., Uppala, R., Billi, A. C., ... & Gudjonsson, J. E. (2021). IRAK2 has a critical role in promoting feed-forward amplification of epidermal inflammatory responses. Journal of Investigative Dermatology, 141(10), 2436-2448.

Yu, C. C., Chan, M. W., Lin, H. Y., Chiou, W. Y., Lin, R. I., Chen, C. A., ... & Hung, S. K. (2021). IRAK2, an IL1R/TLR immune mediator, enhances radiosensitivity via modulating caspase 8/3-mediated apoptosis in oral squamous cell carcinoma. Frontiers in Oncology, 11, 647175.

Xiao, T., Sun, C., Xiao, Y., & Li, Y. (2020). lncRNA NEAT1 mediates sepsis progression by regulating Irak2 via sponging miR-370-3p. Biology open, 9(6), bio049353.

Chen, Z., Zhou, J., Wang, X., Zhang, Y., Lu, X., Fan, Y., ... & Yang, Z. (2019). Screening candidate microR-15a-IRAK2 regulatory pairs for predicting the response to Staphylococcus aureus-induced mastitis in dairy cows. Journal of Dairy Research, 86(4), 425-431.

Guo, S., Chen, Y., Liu, J., Yang, J., Yang, C., Zhang, T., ... & Deng, G. (2019). miR‐497a‐5p attenuates lipopolysaccharide‐induced inflammatory injury by targeting IRAK2. Journal of cellular physiology, 234(12), 22874-22883.

Liu, J., Chen, Y., Huang, Q., Liu, W., Ji, X., Hu, F., ... & Dong, G. (2018). IRAK2 counterbalances oncogenic Smurf1 in colon cancer cells by dictating ER stress. Cellular Signalling, 48, 69-80.

Xu, Y., Liu, H., Liu, S., Wang, Y., Xie, J., Stinchcombe, T. E., ... & Wei, Q. (2018). Genetic variant of IRAK2 in the toll‐like receptor signaling pathway and survival of non‐small cell lung cancer. International journal of cancer, 143(10), 2400-2408.

Liu, H., Yang, X., Zhang, Z. K., Zou, W. C., & Wang, H. N. (2018). miR-146a-5p promotes replication of infectious bronchitis virus by targeting IRAK2 and TNFRSF18. Microbial pathogenesis, 120, 32-36.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Alternative Versions

Human Recombinant IRAK2, Active protein, GST Tag (CAT#: V2LY-0526-LY5059)

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Isotype control

For research use only. Not intended for any clinical use.

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