ITFG2

ITFG2 (Integrin Alpha FG-GAP Repeat Containing 2) is a Protein Coding gene.
Full Name
Integrin Alpha FG-GAP Repeat Containing 2
Function
As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway. Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases. Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids. In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated. The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose.
Biological Process
Cellular response to amino acid starvationManual Assertion Based On ExperimentIMP:UniProtKB
Cellular response to glucose starvationManual Assertion Based On ExperimentIMP:UniProtKB
Germinal center B cell differentiationIEA:Ensembl
Negative regulation of TORC1 signalingManual Assertion Based On ExperimentIMP:UniProtKB
Regulation of TOR signalingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Lysosome membrane. Localization to lysosomes is amino acid-independent.
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Anti-ITFG2 antibodies

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Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I2032) (CBMAB-I3202-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2032
Application*: WB, IH, IF
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I1872) (CBMAB-I3042-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1872
Application*: WB, F
Datasheet SDS

ITFG2 Matched Antibody Pair (650) (APMAB-650LY)

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Target: ITFG2
Specificity: Human
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (2E8) (CBMAB-A5363-LY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Human
Clone: 2E8
Application*: WB, E
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I2054) (CBMAB-I3224-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2054
Application*: WB
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I2017) (CBMAB-I3187-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2017
Application*: WB, IF
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I2016) (CBMAB-I3186-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I2016
Application*: WB
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I2013) (CBMAB-I3183-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Monkey
Clone: CBYY-I2013
Application*: WB, IH
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I2012) (CBMAB-I3182-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I2012
Application*: IF, F
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (CBYY-I1870) (CBMAB-I3040-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I1870
Application*: WB, IF, F
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (2H5) (CBMAB-I0716-YY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 2H5
Application*: F, IF, WB
Datasheet SDS

Mouse Anti-ITFG2 Recombinant Antibody (CBFYM-1158) (CBMAB-M1315-FY)

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Target: ITFG2
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Monkey
Clone: CBFYM-1158
Application*: WB, IH, IF, P
Datasheet SDS
More Infomation
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(P): Predicted
* Abbreviations
  • AActivation
  • AGAgonist
  • APApoptosis
  • BBlocking
  • BABioassay
  • BIBioimaging
  • CImmunohistochemistry-Frozen Sections
  • CIChromatin Immunoprecipitation
  • CTCytotoxicity
  • CSCostimulation
  • DDepletion
  • DBDot Blot
  • EELISA
  • ECELISA(Cap)
  • EDELISA(Det)
  • ESELISpot
  • EMElectron Microscopy
  • FFlow Cytometry
  • FNFunction Assay
  • GSGel Supershift
  • IInhibition
  • IAEnzyme Immunoassay
  • ICImmunocytochemistry
  • IDImmunodiffusion
  • IEImmunoelectrophoresis
  • IFImmunofluorescence
  • IGImmunochromatography
  • IHImmunohistochemistry
  • IMImmunomicroscopy
  • IOImmunoassay
  • IPImmunoprecipitation
  • ISIntracellular Staining for Flow Cytometry
  • LALuminex Assay
  • LFLateral Flow Immunoassay
  • MMicroarray
  • MCMass Cytometry/CyTOF
  • MDMeDIP
  • MSElectrophoretic Mobility Shift Assay
  • NNeutralization
  • PImmunohistologyp-Paraffin Sections
  • PAPeptide Array
  • PEPeptide ELISA
  • PLProximity Ligation Assay
  • RRadioimmunoassay
  • SStimulation
  • SESandwich ELISA
  • SHIn situ hybridization
  • TCTissue Culture
  • WBWestern Blot
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