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ITGA6

The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Full Name
Integrin Subunit Alpha 6
Function
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity).
Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity).
Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity).
ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778).
ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760).
ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).
Biological Process
Cell-substrate adhesionManual Assertion Based On ExperimentIMP:UniProtKB
Cell-substrate junction assemblyManual Assertion Based On ExperimentTAS:ProtInc
Ectodermal cell differentiationManual Assertion Based On ExperimentIEP:UniProtKB
Integrin-mediated signaling pathwayIEA:UniProtKB-KW
Nail developmentManual Assertion Based On ExperimentIMP:UniProtKB
Negative regulation of extrinsic apoptotic signaling pathwayManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of apoptotic processManual Assertion Based On ExperimentIGI:MGI
Positive regulation of cell migrationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of GTPase activityManual Assertion Based On ExperimentIMP:UniProtKB
Positive regulation of neuron projection developmentISS:UniProtKB
Positive regulation of phosphorylationManual Assertion Based On ExperimentIMP:BHF-UCL
Positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIMP:BHF-UCL
Skin morphogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cell membrane; Cell membrane
Involvement in disease
Epidermolysis bullosa letalis, with pyloric atresia (EB-PA):
An autosomal recessive, frequently lethal, epidermolysis bullosa with variable involvement of skin, nails, mucosa, and with variable effects on the digestive system. It is characterized by mucocutaneous fragility, aplasia cutis congenita, and gastrointestinal atresia, which most commonly affects the pylorus. Pyloric atresia is a primary manifestation rather than a scarring process secondary to epidermolysis bullosa.
Topology
Extracellular: 24-1050
Helical: 1051-1076
Cytoplasmic: 1077-1130
PTM
Isoforms containing segment A, but not segment B, are the major targets for PMA-induced phosphorylation. Phosphorylation occurs on 'Ser-1103' of isoform alpha-6X1X2A. Phosphorylation is not required for the induction of integrin alpha-6A/beta-1 high affinity but may reduce the affinity for ligand.
Undergoes PLAU-mediated cleavage at residues Arg-634-635-Arg in a time-dependent manner to produce processed integrin alpha-6 (alpha6p) (PubMed:11359780, PubMed:15023541, PubMed:17303120).
Production of alpha6p enhances prostate cancer cell invasion and migration (PubMed:17303120).
Palmitoylation by DHHC3 enhances stability and cell surface expression.

Anti-ITGA6 antibodies

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Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1, κ
Specificity: Chicken, Avian
Clone: P2C62C4
Application*: F, IF, IH, IP, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBWJC-3868
Application*: E, F, IF, IH
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: A675
Application*: FC, IF, IHC, WB
Target: ITGA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A674
Application*: IHC, WB
Target: ITGA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: A673
Application*: IHC, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: A672
Application*: FC, IHC, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB279
Application*: IF, FC
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: MAR6
Application*: F
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Rat
Clone: Mab-5A
Application*: C, E, F
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6D277
Application*: FC, IH, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 7H164
Application*: FC, IH, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 5K227
Application*: FC, IH, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: EG1695
Application*: ELISA, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: MP4F10
Application*: F, IH, IP
Target: ITGA6
Host: Human
Antibody Isotype: IgG1
Specificity: Human, Mouse
Clone: CBXC-0871
Application*: F
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: P5G10
Application*: B, IH, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 3H1512
Application*: F, IH
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CB278
Application*: IF, FC
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG
Specificity: Human
Clone: CBAb139
Application*: WB, IH, IF, FC
Target: ITGA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Mouse, Rat
Clone: CBAb138
Application*: WB, IH
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-I0350
Application*: F, IH, C, IP, MC
Target: ITGA6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: NKI-GoH3
Application*: F, FN, C, IP, IH, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Human
Clone: CBYY-I0543
Application*: F, IF, IH
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2a, κ
Specificity: Human, Mouse
Clone: 4C1
Application*: E, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse
Clone: CBYY-I0603
Application*: F, C, IP
Target: ITGA6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: 5F200
Application*: F, IH, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBWJC-2224
Application*: F, WB, IH
Target: ITGA6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Human
Clone: GoH3
Application*: F, IH, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Mouse, Rabbit
Clone: MCP106
Application*: WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rabbit
Clone: MCP20
Application*: IH, IP
Target: ITGA6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Dog, Human, Monkey, Mouse, Pig
Clone: 3H1515
Application*: F, IH, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 450-30A
Application*: F
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 4F10
Application*: F, C, P, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2a
Specificity: Mouse, Dog, Human, Monkey, Pig
Clone: 2Q957
Application*: F, IH, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: 2Q959
Application*: F, IP
Target: ITGA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Human, Dog, Mouse
Clone: 5H14L18
Application*: WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: 6B4
Application*: C, IC/IF, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-I0875
Application*: IC, IH, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human, Rat, Rabbit
Clone: CBYY-I1644
Application*: F, IH, IF, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C0130
Application*: F, IH
Target: ITGA6
Host: Rat
Antibody Isotype: IgG2a
Specificity: Dog, Human, Monkey, Mouse, Pig
Clone: CBYY-C0131
Application*: F, IH, IP
Target: ITGA6
Host: Rabbit
Antibody Isotype: IgG
Specificity: Dog, Human, Mouse
Clone: CBYY-C2596
Application*: WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG2b
Specificity: Human
Clone: CBYY-C2597
Application*: F, IH, IP
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2599
Application*: F, IH, WB
Target: ITGA6
Host: Mouse
Antibody Isotype: IgG1
Specificity: Human
Clone: CBYY-C2598
Application*: C, IF, WB
For Research Use Only. Not For Clinical Use.
(P): Predicted
* Abbreviations
IFImmunofluorescence
IHImmunohistochemistry
IPImmunoprecipitation
WBWestern Blot
EELISA
MMicroarray
CIChromatin Immunoprecipitation
FFlow Cytometry
FNFunction Assay
IDImmunodiffusion
RRadioimmunoassay
TCTissue Culture
GSGel Supershift
NNeutralization
BBlocking
AActivation
IInhibition
DDepletion
ESELISpot
DBDot Blot
MCMass Cytometry/CyTOF
CTCytotoxicity
SStimulation
AGAgonist
APApoptosis
IMImmunomicroscopy
BABioassay
CSCostimulation
EMElectron Microscopy
IEImmunoelectrophoresis
PAPeptide Array
ICImmunocytochemistry
PEPeptide ELISA
MDMeDIP
SHIn situ hybridization
IAEnzyme Immunoassay
SEsandwich ELISA
PLProximity Ligation Assay
ECELISA(Cap)
EDELISA(Det)
BIBioimaging
IOImmunoassay
LFLateral Flow Immunoassay
LALuminex Assay
CImmunohistochemistry-Frozen Sections
PImmunohistologyp-Paraffin Sections
ISIntracellular Staining for Flow Cytometry
MSElectrophoretic Mobility Shift Assay
RIRNA Binding Protein Immunoprecipitation (RIP)
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